Disease progression patterns of SHIV-KB9 in rhesus macaques of Chinese origin in comparison with Indian macaques
Disease progression patterns of SHIV-KB9 in rhesus macaques of Chinese origin in comparison with Indian macaques
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DOI：
10.1016/s0895-3988(08)60046-x
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发表时间：
2008-08-01
影响因子：
3.5
通讯作者：
Shao, Yi-Ming
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Yang, Gui-Bo;Shao, Yi-Ming
目的 建立用于疫苗研究的SHIV-KB9/中国恒河猴（Ch Rh）模型，并将SHIV-KB9在Ch Rh猕猴中的发病机制与报道的印度恒河猴（Ind Rh）猕猴中的发病机制进行比较。方法7只mamu-A*01阴性Ch Rh猕猴静脉接种1-10000 MID50的SHIV-KB9。监测猴子的病毒载量、CD4、CD8、SHIV 特异性抗体和病毒遗传变异。将结果与之前在 Ind Rh 猕猴中观察到的结果进行了比较。结果与 Ind Rh 猕猴中观察到的结果相比，Ch Rh 猕猴中的 SHIV-KB9 显示出三种相同的疾病进展模式。然而，两个亚种之间的主要模式并不相同。感染 SHIV-KB9 的 Ch Rh 猕猴的血浆病毒血症水平不同，表现出与 Ind Rh 猕猴不同的结果。一般来说，病毒载量值和CD4(+) T细胞的维持与不道德反应相关。另外，动物（M419、M425）的病毒遗传距离（分歧、多样性）更大，其 CD4(+) T 细胞严重耗尽。结论 与 Ind Rh 猕猴相比，SHIV-KB9/Ch Rh 猕猴模型显示出 AIDS 进展相对缓慢，这可能更准确地反映了候选疫苗在人类中的潜力。
Objective To develop a model of SHIV-KB9/Chinese origin rhesus (Ch Rh) macaques for vaccine research and to compare the pathogenesis of SHIV-KB9 in Ch Rh macaques with that reported in Indian rhesus (Ind Rh) macaques. Methods Seven mamu-A*01 negative Ch Rh macaques were inoculated intravenously with 1-10000 MID50 of SHIV-KB9. The monkeys were monitored for viral load, CD4, CD8, SHIV-specific antibody and virus genetic variation. The results were compared with those previously observed in Ind Rh macaques. Results As compared to that observed in Ind Rh macaques, SHIV-KB9 in Ch Rh macaques displayed three identical disease progression patterns. However, the primary pattern was not identical between the two subspecies. The level of plasma viremia differed in SHIV-KB9-infected Ch Rh macaques which exhibited different outcomes from those in Ind Rh macaques. Generally, the values of viral load and the maintenance of CD4(+) T cells were associated with Immoral responses. Otherwise, the viral genetic distances (divergence, diversity) were larger in animals (M419, M425) with their CD4(+) T cells profoundly depleted. Conclusion The model of SHIV-KB9/Ch Rh macaques displays a relatively slow progression to AIDS compared with Ind Rh macaques, which may more accurately reflect the potential of candidate vaccines in humans.