The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment.
The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment.
复制标题
DOI：
10.1080/2162402x.2018.1434467
复制
发表时间：
2018
期刊：
影响因子：
7.2
通讯作者：
Redmond WL
中科院分区：
文献类型：
--
作者：
Farhad M;Rolig AS;Redmond WL
肿瘤微环境(TME)中存在多种免疫抑制机制，这在一定程度上限制了肿瘤免疫治疗的效果。半乳糖凝集素-3(Galectin-3，Gal-3)是一种凝集素，参与TME免疫抑制，调节细胞内环境平衡和肿瘤生物学等多种功能。肿瘤进展过程中Gal-3表达的增加增加了肿瘤的生长、侵袭性、转移潜能和免疫抑制，这突显了Gal-3作为能够调节抗肿瘤免疫的治疗靶点的潜在用途。在这里，我们讨论了Gal-3调节淋巴细胞的机制，Gal-3在肺和前列腺癌中的作用，以及Gal-3在TME免疫抑制中的作用。
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mechanisms present within the tumor microenvironment (TME). Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates diverse functions including cellular homeostasis and cancer biology. Increased Gal-3 expression during cancer progression augments tumor growth, invasiveness, metastatic potential, and immune suppression, which highlights the potential use of Gal-3 as a therapeutic target capable of modulating anti-tumor immunity. Here, we discuss the mechanisms by which Gal-3 regulates lymphocytes, the role of Gal-3 in lung and prostate tumors, and the contribution of Gal-3 to TME immunosuppression.