Interpreting patient/informant discrepancies of reported cognitive symptoms in MS
Interpreting patient/informant discrepancies of reported cognitive symptoms in MS
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DOI：
10.1017/s135561770505068x
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发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Weinstock-Guttman, B
中科院分区：
文献类型：
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作者：
Carone, DA;Benedict, RHB;Weinstock-Guttman, B
虽然许多研究表明，脑损伤患者倾向于低估神经心理（NP）损伤时，自我评级相比，告密者的评级，这种差异的意义是没有很好地研究多发性硬化症（MS）。我们比较了122名MS患者和37名年龄和教育程度匹配的正常对照组的NP功能的患者自我和报告问卷评分。除了完成多发性硬化症神经心理问卷（MSNQ）外，参与者还接受了NP测试和抑郁，人格评估。和神经精神症状根据认知能力评分的正态分布，患者根据他们是否高估或低估了自己的认知能力进行分类，相对于告密者的评级。方差分析比较测试分数来自高估，低估，准确的估计是显着的认知功能的多个措施。抑郁、人格和神经精神症状。高估者的特点是较少抑郁和焦虑。和更大程度的认知障碍，欣快的行为去抑制。与低估者相比，我们的结论是，患者/知情人的差异分数的MSNQ与上述神经精神功能，和MSNQ有潜在的效用，用于预测欣快症和抑制解除综合征在MS。
Although numerous studies have shown that brain-damaged patients tend to underestimate neuropsychological ( NP) impairment when self-ratings are compared to informant ratings, the meaning of such discrepancies is not well studied in multiple sclerosis (MS). We compared patient self- and informant-report questionnaire rating's of NP functioning in 122 MS patients and 37 age- and education-matched normal controls. In addition to completing the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), participants underwent NP testing and assessment of depression, personality. and neuropsychiatric symptoms. Based on the normal distribution of dicrepancy scores, patients were classified according to whether they overestimated or underestimated their cognitive ability, relative to informant ratings. ANOVAs comparing test scores derived from overestimators, underestimators, and accurate estimators were significant for multiple measures of cognitive function. depression, personality, and neuropsychiatric symptoms. Overestimators were characterized by less depression and conscientiousness. and greater degrees of cognitive impairment, euphoric behavioral disinhibition. and unemployment as compared to underestimators. We conclude that patient/informant discrepancy scores on the MSNQ are associated with the aforementioned neuropsychiatric features, and that the MSNQ has potential utility for predicting euphoria and disinhibition syndromes in MS.