Arsenic Exposure During Pregnancy and Size at Birth: A Prospective Cohort Study in Bangladesh
Arsenic Exposure During Pregnancy and Size at Birth: A Prospective Cohort Study in Bangladesh
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DOI：
10.1093/aje/kwn332
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发表时间：
2009-02-01
影响因子：
5
通讯作者：
Ekstrom, Eva-Charlotte
中科院分区：
文献类型：
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作者：
Rahman, Anisur;Vahter, Marie;Ekstrom, Eva-Charlotte
作者评估了产前砷暴露与出生时体型（出生体重、出生身长、头围和胸围）的关系。2002-2003年，在孟加拉国的Matlab对1 578对母婴进行了这项前瞻性队列研究。砷暴露通过分析在妊娠第8周和第30周收集的尿液中的砷进行评估。砷暴露与出生时的大小的关联进行了评估线性回归分析。在对整个接触范围（6-978微克/升）的分析中，未发现与出生大小的剂量效应相关性。然而，在低水平砷暴露（尿中< 100 μ g/L）下，发现出生体重、头围和胸围有显著的负剂量效应。在这个范围内的接触，出生体重下降了1.68（标准误差（SE），0.62）克每增加1微克/升的尿中砷。对于头围和胸围，相应的减少分别为0.05（SE，0.03）mm和0.14（SE，0.03）mm/1 μ g/L。在较高的砷暴露水平下，没有进一步的负面影响。低水平砷暴露对出生大小的负面影响值得进一步研究。
The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences). This prospective cohort study, based on 1,578 mother-infant pairs, was conducted in Matlab, Bangladesh, in 2002-2003. Arsenic exposure was assessed by analysis of arsenic in urine collected at around gestational weeks 8 and 30. The association of arsenic exposure with size at birth was assessed by linear regression analyses. In analysis over the full range of exposure (6-978 mu g/L), no dose-effect association was found with birth size. However, significant negative dose effects were found with birth weight and head and chest circumferences at a low level of arsenic exposure (< 100 mu g/L in urine). In this range of exposure, birth weight decreased by 1.68 (standard error (SE), 0.62) g for each 1-mu g/L increase of arsenic in urine. For head and chest circumferences, the corresponding reductions were 0.05 (SE, 0.03) mm and 0.14 (SE, 0.03) mm per 1 mu g/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation.