Female gout: clinical and laboratory features.
Female gout: clinical and laboratory features.
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发表时间：
2005-11
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通讯作者：
A. D. de Souza;V. Fernandes;A. J. Ferrari
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作者：
A. D. de Souza;V. Fernandes;A. J. Ferrari
目的评价和比较男性和女性痛风的临床和实验室特点。方法对27例女性痛风患者和31例男性痛风患者进行临床和实验室检查，并复习病历。结果女性发病时间平均比男性晚7年。在全身性高血压、糖尿病、高脂血症、慢性肾功能衰竭、肾结石、缺血性心脏病或酗酒方面，女性和男性之间没有差异。两组的痛风相似，尽管女性似乎对发生痛风的风险有保护作用(优势比：0.449；95%可信区间：0.151-1.330)。Podagra在男性中更常见，女性上肢关节受累的频率更高。大多数患者尿酸盐排泄率较低。在女性和男性中实现疾病控制是相似的。在8名发病时处于绝经前的妇女中，有7人有痛风的继发性原因；8人中有5人尽管接受了治疗，但仍有高血尿酸。结论女性痛风起病较晚，上肢关节受累的发生率高于男性。那些绝经前发病的患者往往对标准治疗难以奏效。
OBJECTIVE To evaluate and compare clinical and laboratory features of gout in men and women. METHODS Twenty-seven women and 31 men with gout underwent clinical and laboratory evaluation and review of medical records. RESULTS Disease onset in women was a mean of 7 years later than in men. There were no differences between women and men regarding systemic hypertension, diabetes mellitus, hyperlipidemia, chronic renal failure, renal stones, ischemic heart disease, or heavy alcohol consumption. Tophaceous gout was similar in both groups, although female gender seemed to be protective against risk of developing tophi (odds ratio: 0.449; 95% confidence interval: 0.151-1.330). Podagra was more common in men, and women showed a higher frequency of upper limb joint involvement. Most patients had low urate excretion rates. Achieving disease control was similar in women and men. Of the 8 women who were premenopausal at disease onset, 7 had secondary causes for gout; 5 of the 8 had high serum urate despite treatment. CONCLUSION Gout in women had a later onset and higher frequency of upper limb joint involvement in comparison to men. Those with premenopausal onset tended to be refractory to standard therapy.