Gradual changes in hippocampal activity support remembering the order of events
Gradual changes in hippocampal activity support remembering the order of events
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DOI：
10.1016/j.neuron.2007.08.017
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发表时间：
2007-11-08
期刊：
影响因子：
16.2
通讯作者：
Eichenbaum, Howard
中科院分区：
文献类型：
--
作者：
Manns, Joseph R.;Howard, Marc W.;Eichenbaum, Howard
海马体被认为部分通过将刺激与其时空背景结合来促进情节记忆。本研究探讨了海马神经元群体如何编码的空间和时间的背景下，大鼠进行了一项任务，在该任务中，他们被要求记住的审判独特的序列的气味。研究结果表明，海马活动模式的逐渐变化作为气味采样事件的时间背景，并为这些气味的顺序成功的后续记忆是重要的。
The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.