GM-CSF RAPIDLY PRIMES MICE FOR ENHANCED CYTOKINE PRODUCTION IN RESPONSE TO LPS AND TNF
GM-CSF RAPIDLY PRIMES MICE FOR ENHANCED CYTOKINE PRODUCTION IN RESPONSE TO LPS AND TNF
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DOI：
10.1006/cyto.1995.0035
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发表时间：
1995-04-01
期刊：
影响因子：
3.8
通讯作者：
GRIFFITHS, RJ
中科院分区：
文献类型：
--
作者：
BRISSETTE, WH;BAKER, DA;GRIFFITHS, RJ
给小鼠皮下注射粒细胞-巨噬细胞-集落刺激因子（GM-CSF）增强了LPS诱导的循环（TNF、IL-6）和腹膜腔（TL-1β、IL-6）中细胞因子的产生，这种作用迅速诱导（1小时内）并持续4小时，用环磷酰胺使白细胞减少的小鼠保留了对GM-CSE做出反应的能力。此外，TNF诱导的IL-6产生也被抑制。这些结果表明，GM-CSF 对体内产生细胞因子的细胞具有显着的启动作用，并提出了这种细胞因子可能导致感染性休克发病机制的可能性。
Subcutaneous administration of Granulocyte-macrophage - colony stimulating factor (GM-CSF) to mice enhanced LPS-induced cytokine production in the circulation (TNF, IL-6) and peritoneal cavity (TL-1 beta, IL-6), This effect was induced rapidly (within 1 h) and persisted for 4 h, Mice made leukopenic with cyclophosphamide retained the ability to respond to GM-CSE In addition, TNF induced IL-6 production was also enhanced, These results demonstrate that GM-CSF has a pronounced priming effect on cytokine producing cells in vivo and raises the possibility that this cytokine may contribute to the pathogenesis of septic shock.