ASSOCIATIVE ODOR LEARNING IN DROSOPHILA ABOLISHED BY CHEMICAL ABLATION OF MUSHROOM BODIES
ASSOCIATIVE ODOR LEARNING IN DROSOPHILA ABOLISHED BY CHEMICAL ABLATION OF MUSHROOM BODIES
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DOI：
10.1126/science.8303280
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发表时间：
1994-02-04
期刊：
影响因子：
56.9
通讯作者：
HEISENBERG, M
中科院分区：
文献类型：
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作者：
DEBELLE, JS;HEISENBERG, M
黑腹果蝇（Drosophila melanogaster）成虫脑中的有柄小体（或蘑菇体）由大约2500个平行的Kenyon细胞纤维组成，这些纤维来自4个MB神经母细胞。喂给新孵化的幼虫的羟基脲选择性地删除这些细胞，导致完全、精确的MB消融。成年苍蝇发展没有MB的行为在大多数方面正常，但无法执行经典的条件反射范式，测试联想学习的气味线索和电击。这种缺陷不能归因于嗅觉敏感性、休克反应性或运动行为的降低。结果表明，MBs介导果蝇的联想气味学习。
The corpora pedunculata, or mushroom bodies (MBs), in the brain of Drosophila melanogaster adults consist of approximately 2500 parallel Kenyon cell fibers derived from four MB neuroblasts. Hydroxyurea fed to newly hatched larvae selectively deletes these cells, resulting in complete, precise MB ablation. Adult flies developing without MBs behave normally in most respects, but are unable to perform in a classical conditioning paradigm that tests associative learning of odor cues and electric shock. This deficit cannot be attributed to reductions in olfactory sensitivity, shock reactivity, or locomotor behavior. The results demonstrate that MBs mediate associative odor learning in flies.