Human Blood and Plasma Partition Coefficients for C4-C8 n-alkanes, Isoalkanes, and 1-alkenes
Human Blood and Plasma Partition Coefficients for C4-C8 n-alkanes, Isoalkanes, and 1-alkenes
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DOI：
10.1177/1091581812442689
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发表时间：
2012-03-01
影响因子：
2.2
通讯作者：
Amann, Anton
中科院分区：
文献类型：
--
作者：
Mochalski, Pawel;King, Julian;Amann, Anton
人血：空气和血浆：采用多重顶空萃取与固相微萃取和气相色谱相结合的方法测定了C-4-C-8正构烷烃、异构烷烃和1-烯烃的空气分配系数。C-4-C-8正构烷烃的平均血-气分配系数分别为0.183、0.416、0.416、1.08、2.71和5.77，C-4-C-8异构烷烃的平均血-气分配系数分别为0.079、0.184、0.473、1.3和3.18；C-4-C-8 1-烯烃分别为0.304、0.589、1.32、3.5和7.0 1。所报道的分配系数值随沸点、分子质量和颗粒中的碳原子呈指数增加。1-烯烃在血液中的溶解度高于在血浆中的溶解度，但正构烷烃和异构烷烃在血液：空气和血浆：空气中的分配系数没有显著差异。因此，1-烯烃与全血的额外相互作用似乎发生了。目前的研究结果有望对评估碳氢化合物在人体内的吸收、分布和消除特别有用。
Human blood:air and plasma:air partition coefficients for C-4-C-8 n-alkanes, isoalkanes, and 1-alkenes were determined using multiple headspace extraction coupled with solid phase microextraction and gas chromatography. Mean blood:air partition coefficients expressed in the form of dimensionless blood-to-air concentration ratio (g/mL(b)/g/mL(a)) were 0.183, 0.416, 1.08, 2.71, and 5.77 for C-4-C-8 n-alkanes; 0.079, 0.184, 0.473, 1.3, and 3.18 for C-4-C-8 isoalkanes; and 0.304, 0.589, 1.32, 3.5, and 7.01 for C-4-C-8 1-alkenes, respectively (n = 8). The reported partition coefficient values increased exponentially with boiling points, molecular weights, and the carbon atoms in the particle. The solubility of 1-alkenes in blood was higher than in plasma, whereas the blood:air and plasma:air partition coefficients of n-alkanes and isoalkanes did not differ significantly. Consequently, additional interactions of 1-alkenes with whole blood seem to occur. The presented findings are expected to be particularly useful for assessing the uptake, distribution, and elimination of hydrocarbons in human organism.