Retino-Cortical Mapping Ratio Predicts Columnar and Salt-and-Pepper Organization in Mammalian Visual Cortex
Retino-Cortical Mapping Ratio Predicts Columnar and Salt-and-Pepper Organization in Mammalian Visual Cortex
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DOI：
10.1016/j.celrep.2020.02.038
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发表时间：
2020-03-10
期刊：
影响因子：
8.8
通讯作者：
Paik, Se-Bum
中科院分区：
文献类型：
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作者：
Jang, Jaeson;Song, Min;Paik, Se-Bum
在哺乳动物的初级视觉皮层中，不同物种对刺激方向的神经调节以柱状或盐-胡椒模式组织。几十年来，这种鲜明的对比引发了关于视觉皮层功能结构起源的基本问题。然而，尚不清楚这些模式是否反映了不同哺乳动物类群的不同发育机制，还是仅仅源于普遍发育过程中生物参数的变化。在这项工作中，在分析了来自8种哺乳动物物种的数据后，我们表明皮质组织是由单一因素预测的，即视网膜-皮质映射比。有或没有柱状聚类的物种群是通过前馈采样率来区分的，在控制映射条件下的模型模拟再现了这两种类型的组织。奈奎斯特定理的预测高精度地解释了这种模式的参数划分。我们的研究结果表明，物理参数的进化变化可能导致不同功能电路的发展。
In the mammalian primary visual cortex, neural tuning to stimulus orientation is organized in either columnar or salt- and-pepper patterns across species. For decades, this sharp contrast has spawned fundamental questions about the origin of functional architectures in visual cortex. However, it is unknown whether these patterns reflect disparate developmental mechanisms across mammalian taxa or simply originate from variation of biological parameters under a universal development process. In this work, after the analysis of data from eight mammalian species, we show that cortical organization is predictable by a single factor, the retino-cortical mapping ratio. Groups of species with or without columnar clustering are distinguished by the feedforward sampling ratio, and model simulations with controlled mapping conditions reproduce both types of organization. Prediction from the Nyquist theorem explains this parametric division of the patterns with high accuracy. Our results imply that evolutionary variation of physical parameters may induce development of distinct functional circuitry.