Osteoprotegerin ligand: a regulator of immune responses and bone physiology
Osteoprotegerin ligand: a regulator of immune responses and bone physiology
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DOI：
10.1016/s0167-5699(00)01718-7
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发表时间：
2000-10-01
期刊：
影响因子：
--
通讯作者：
Penninger, JM
中科院分区：
文献类型：
--
作者：
Kong, YY;Boyle, WJ;Penninger, JM
tnf家族分子骨保护素配体（OPGL，也称为TRANCE、RANKL和ODF）是骨重塑的关键调节剂，对破骨细胞的发育和激活至关重要。有趣的是，OPGL还调节T细胞-树突状细胞通讯，树突状细胞存活和淋巴结器官发生。在这里，Young-Yun Kong及其同事讨论了OPGL及其受体RANK在免疫系统和骨代谢中的作用。
The TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell-dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.