Impact of microgravity on radiobiological processes and efficiency of DNA repair
Impact of microgravity on radiobiological processes and efficiency of DNA repair
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DOI：
10.1016/s0027-5107(99)00133-5
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发表时间：
1999-12-06
影响因子：
2.3
通讯作者：
Horneck, G
中科院分区：
文献类型：
--
作者：
Horneck, G
为了研究微重力对空间放射生物学过程的影响，进行了空间实验，使用一台机载1xg参考离心机作为飞行中控制。个别重离子的轨迹是本地化相对于生物系统的使用的生物堆栈的概念，或额外的高剂量的辐射被施加之前的使命或在使命从一个板载的辐射源。在胚胎系统中，如黑腹果蝇和红腹Carausius marosus的早期发育阶段，染色体易位和幼虫畸形的发生率因微重力和辐射而急剧增加。据推测，这些协同效应可能是由微重力干扰DNA修复过程造成的。然而，最近对细菌、酵母细胞和人类成纤维细胞的研究表明，微重力环境中细胞修复过程的紊乱可能不能完全解释所报告的辐射和微重力的协同作用。作为另一种解释，应当考虑微重力对细胞一级的信号转导、代谢/生理状态或染色质结构的影响，或对组织和器官一级的自组装、细胞间通讯、细胞迁移、模式形成或分化的改变的影响。(C)1999 Elsevier Science B. V.保留所有权利。
To study the influence of microgravity on radiobiological processes in space, space experiments have been performed, using an on-board 1 x g reference centrifuge as in-flight control. The trajectory of individual heavy ions was localized in relation to the biological systems by use of the Biostack concept, or an additional high dose of radiation was applied either before the mission or during the mission from an on-board radiation source. In embryonic systems, such as early developmental stages of Drosophila melanogaster and Carausius marosus, the occurrence of chromosomal translocations and larval malformations was dramatically increased in response to microgravity and radiation. It has been hypothesized that these synergistic effects might be caused by an interference of microgravity with DNA repair processes. However, recent studies on bacteria, yeast cells and human fibroblasts suggest that a disturbance of cellular repair processes in the microgravity environment might not be a complete explanation for the reported synergism of radiation and microgravity. As an alternative explanation, an impact of microgravity on signal transduction, on the metabolic/physiological state or on the chromatin structure at the cellular level, or modification of self-assembly, intercellular communication, cell migration, pattern formation or differentiation at the tissue and organ level should be considered. (C) 1999 Elsevier Science B.V. All rights reserved.