Relationship between soluble P-selectin and inflammatory factors (interleukin-6 and C-reactive protein) in colorectal cancer
Relationship between soluble P-selectin and inflammatory factors (interleukin-6 and C-reactive protein) in colorectal cancer
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DOI：
10.1016/j.thromres.2006.11.002
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发表时间：
2007-01-01
影响因子：
7.5
通讯作者：
Kemona, Halina
中科院分区：
文献类型：
--
作者：
Dymicka-Piekarska, Violetta;Matowicka-Karna, Joanna;Kemona, Halina
背景：血小板是血栓形成过程、炎症和癌症进展中的重要因素。方法：检测42例结直肠癌患者和38例健康对照者的可溶性P-选择素（血小板活化标志物）、白细胞介素-6（IL-6）和C-反应蛋白（CRP）水平。CRC患者分为两组：A-24例I期和II期患者; B-18例III期患者。可溶性P-选择素、白细胞介素-6浓度使用市售免疫酶法测量。结果：与对照组相比，急性心肌梗死患者血清可溶性P-选择素、CRP和IL-6水平均显著升高（P < 0.001）。B组（有转移）血浆sP-选择素、CRP和IL-6水平高于A组（无转移）（p < 0.001）。结直肠癌患者IL-6与CRP呈正相关（r=0.7638，p < 0.01），sP-选择素与IL-6呈正相关（r=0.5633，p < 0.03）。结论：结直肠癌患者存在血小板过度活化和炎症反应，炎症过程和血小板活化沿着结直肠癌的进展。我们的结果似乎证实了结直肠癌患者血小板活化与炎症反应的关系。(c)2006爱思唯尔有限公司保留所有权利。
Background: Platelets are an important element in the thrombotic process, inflammation and cancer progression. We tested the hypothesis that there is a relationship between platelet activation and inflammation in colorectal cancer patients(CRC).Patients/Methods: We measured soluble (s) P-selectin (marker of platelet activation), interleukin-6 (IL-6) and C-reactive protein (CRP) (indexes of inflammation) in 42 CRC patients and 38 healthy subjects. CRC patients were divided into two groups: A-24 patients in stages I and II; B-18 patients in stage III. Soluble P-selectin, Interleukin-6 concentration was measured using commercially available immunoenzymatic methods. High sensitivity C-reactive protein (RCRP) concentration was measured by a high sensitivity latex particle turbidimetric immunoassay.Results: Soluble P-selectin, CRP and IL-6 levels were significantly increased as compared to the control group (p < 0.001). Plasma levels of sP-selectin, CRP and IL-6 were higher in group B (with metastases) than in group A (without metastases) (p < 0.001). CRC patients had a positive correlation between IL-6 and CRP (r=0.7638, p < 0.01) and between sP-selectin and IL-6 (r=0.5633, p < 0.03).Conclusion: We observed hyperactivation of blood platelets and inflammatory response in patients with colorectal cancer, also the inflammatory process and p latelet activation progress along with colorectal cancer advancement. Our results, seem to confirm the relationship of platelet activation with inflammatory response in colorectal cancer patients. (c) 2006 Elsevier Ltd. All rights reserved.