Chondroitin Sulfate in Human Cutaneous Meissner and Pacinian Sensory Corpuscles
Chondroitin Sulfate in Human Cutaneous Meissner and Pacinian Sensory Corpuscles
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DOI：
10.1002/ar.23951
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发表时间：
2019-02-01
影响因子：
2
通讯作者：
Garcia-Suarez, Olivia
中科院分区：
文献类型：
--
作者：
Garcia-Piqueras, Jorge;Carcaba, Lucia;Garcia-Suarez, Olivia
硫酸软骨素是一种糖胺聚糖，参与维持外周神经细胞外基质的形态功能特性，但其在人感觉小体中的分布是未知的，尽管细胞外基质在机械传导和轴突引导中的作用。本研究采用免疫组织化学方法分析硫酸软骨素在人皮肤触觉小体和环层小体中的分布。硫酸软骨素表达缺席迈斯纳小体。在Pacinian小体硫酸软骨素被发现与CD 34阳性神经内膜相关层，插入之间的S100蛋白阳性内核细胞，波形蛋白阳性内核和外核囊细胞。因此，环层小体中存在的中间CD 34 +/硫酸软骨素+中间层将小体的神经节段（轴突和内核）与非神经节段（外核和囊）隔离。这些结果表明，硫酸软骨素的作用，在适当的轴突生长和指导，在环层小体的神经元隔室在发展和神经再支配，可以假设。此外，不能排除CS在机械转导中的作用。Anat Rec，302：325-331，2019。(c)2018年威利期刊公司
Chondroitin sulfate is a glycosaminoglycan involved in maintaining the morphofunctional properties of the extracellular matrix in peripheral nerves, but its distribution in human sensory corpuscles is unknown despite the role of extracellular matrix in mechanotransduction and axonal guidance. In this study we used immunohistochemistry to analyze the distribution of chondroitin sulfate in human cutaneous Meissner and Pacinian corpuscles. Chondroitin sulfate expression was absent from Meissner corpuscles. In Pacinian corpuscles chondroitin sulfate was found associated to a CD34 positive endoneurial-related layer, interposed between the S100 protein positive inner core cells, and the vimentin positive inner core and outer core-capsule cells. Therefore, the intermediate CD34+/chondroitin sulfate+ intermediate layer present in Pacinian corpuscles isolates the neural segment of the corpuscles (axon and inner core) from the non-neural segments (outer core and capsule). These results suggest a role of chondroitin sulfate in the proper axonal growth and guidance, within the neuronal compartment of the Pacinian corpuscles during development and reinnervation, can be hypothesized. Moreover, a role of CS in mechanotransduction cannot be ruled out. Anat Rec, 302:325-331, 2019. (c) 2018 Wiley Periodicals, Inc.