Analysis of dynamic radioligand displacement or ''activation'' studies
Analysis of dynamic radioligand displacement or ''activation'' studies
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DOI：
10.1097/00004647-199701000-00011
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发表时间：
1997-01-01
影响因子：
6.3
通讯作者：
Nutt, DJ
中科院分区：
文献类型：
--
作者：
Friston, KJ;Malizia, AL;Nutt, DJ
我们提出了一个简单的方法来评估动态或时间依赖性的变化，位移在单一主题放射性配体正电子发射断层扫描（PET）激活研究。该方法旨在促进使用选择性放射性配体的动态活化研究。原则上，这些研究能够通过类比使用rCBF激活研究的功能神经解剖学研究来表征功能神经化学。该方法结合了时间依赖性的示踪剂动力学房室模型和统计参数映射中使用的一般线性模型。这为全面、基于体素和以数据为主导的区域具体影响评估提供了条件。本文中提出的统计模型是基于单室模型预测的，该模型扩展到允许动力学的时间依赖性变化。我们已经解决了灵敏度和特异性的分析，因为它将被用于操作，通过应用C-11-氟马西尼动态位移研究的分析。本示范研究中使用的激活是示踪剂给药后30分钟的药理学（静脉咪达唑仑）激发。我们能够证明，并作出统计推断，区域增加k（2）（或减少的体积分布）在前额和其他皮质区。
We present a simple way of assessing dynamic or time-dependent changes in displacement during single-subject radioligand positron emission tomography (PET) activation studies. The approach is designed to facilitate dynamic activation studies using selective radioligands. These studies are, in principle, capable of characterising functional neurochemistry by analogy with the study of functional neuroanatomy using rCBF activation studies. The proposed approach combines time-dependent compartmental models of tracer kinetics and the general linear model used in statistical parametric mapping. This provides for a comprehensive, voxel-based and data-led assessment of regionally specific effects. The statistical model proposed in this paper is predicated on a single-compartment model extended to allow for time-dependent changes in kinetics. We have addressed the sensitivity and specificity of the analysis, as it would be used operationally, by applying the analysis to C-11-Flumazenil dynamic displacement studies. The activation used in this demonstration study was a pharmacological (i.v. midazolam) challenge, 30 min after administration of the tracer. We were able to demonstrate, and make statistical inferences about, regional increases in k(2) (or decreases in the volume of distribution) in prefrontal and other cortical areas.