Frontal and temporal dopamine release during working memory and attention tasks in healthy humans:: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
Frontal and temporal dopamine release during working memory and attention tasks in healthy humans:: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
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DOI：
10.1523/jneurosci.2097-04.2005
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发表时间：
2005-03-09
影响因子：
5.3
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Aalto, S;Brück, A;Rinne, JO
对动物的实验研究表明，多巴胺是调节前额皮质工作记忆（WM）功能的关键神经递质。在人类中，血流研究表明前额叶参与 WM 功能，但缺乏多巴胺能系统参与 WM 的直接证据。使用正电子发射断层扫描和最近开发的高亲和力多巴胺 D-2 受体示踪剂 [C-11] FLB 457，我们探索了 12 名健康志愿者在执行言语 WM 和持续注意力任务时额叶、颞叶和顶叶 D-2 受体的可用性。在执行这两项任务期间，在左腹侧前扣带回中观察到 D-2 受体可用性降低，表明在这些任务期间注意力或唤醒相关的多巴胺释放增加。与持续注意力任务相比，言语 WM 任务降低了双侧腹外侧额叶皮质和左侧内侧颞叶结构（杏仁核、海马）中 D-2 受体的可用性，表明这些区域的多巴胺释放可能在 WM 中具有特定作用。此外，相关分析表明，在 WM 任务期间，右腹外侧额叶皮层和左腹前扣带皮层多巴胺释放的增加分别与更快和更稳定的 WM 表现相关。我们的结果表明，额颞叶多巴胺能网络的区域特定组成部分在功能上参与人类 WM 表现。
Experimental studies on animals have shown that dopamine is a key neurotransmitter in the regulation of working memory (WM) functions in the prefrontal cortex. In humans, blood flow studies show prefrontal involvement in WM functions, but direct evidence for the involvement of the dopaminergic system in WM is lacking. Using positron emission tomography with a recently developed high-affinity dopamine D-2 receptor tracer, [C-11] FLB 457, we explored frontal, temporal, and parietal D-2 receptor availability in 12 healthy volunteers while they were performing verbal WM and sustained attention tasks. During the performance of both tasks, reduced D-2 receptor availability was observed in the left ventral anterior cingulate, suggesting an attention or arousal-related increase in dopamine release during these tasks. Compared with the sustained attention task, the verbal WM task reduced D-2 receptor availability in the ventrolateral frontal cortex bilaterally and in the left medial temporal structures (amygdala, hippocampus), suggesting that dopamine release in these regions might have a specific role in WM. In addition, correlation analyses indicated that increased dopamine release in the right ventrolateral frontal cortex and the left ventral anterior cingulate during the WM task was associated with faster and more stable WM performance, respectively. Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans.