Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study.
Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study.
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DOI：
10.1161/circulationaha.109.853895
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发表时间：
2009-09-29
期刊：
影响因子：
37.8
通讯作者：
Aviv A
中科院分区：
文献类型：
--
作者：
Vasan RS;Demissie S;Kimura M;Cupples LA;White C;Gardner JP;Cao X;Levy D;Benjamin EJ;Aviv A
由于氧化应激、炎症和暴露于血管危险因素的累积负担，白细胞端粒长度（LTL）在成年过程中会减少。左心室（LV）质量是长期暴露于心血管疾病危险因素的生物标志物。我们假设LTL与LV质量呈负相关。我们使用多变量线性回归校正年龄、性别、身高、体重、收缩压、高血压治疗和吸烟，将LTL（Southern印迹分析测量）与850名心脏病研究参与者（平均年龄58岁，58%为女性）的超声心动图左室质量及其组分（左室舒张期内径，LVDD;左室壁厚度，LVWT）相关。总体而言，多变量调整的LTL与LV质量（每SD增加的β系数[β]=0.072; p= 0.001）、LVWT（β=0.053; p= 0.01）和LVDD（β=0.035; p= 0.09）呈正相关。我们观察到高血压状态对效应的影响（对于LV质量，相互作用p =0.02）;在高血压患者中，LTL与LV质量和LVWT的相关性更强（β/SD增量分别为0.10和0.08;两者p<0.01）。左室质量最高四分位数的高血压参与者的LTL比最低四分位数的参与者长250个碱基对（四分位数趋势p <0.009）。与我们的预期相反，在我们以社区为基础的样本中，LTL与左室质量和室壁厚度呈正相关，尤其是在高血压患者中。这些数据与LTL较长可能是LV肥大倾向标志的假设一致。
Leukocyte telomere length (LTL) decreases over the adult life course due to the cumulative burden of oxidative stress, inflammation, and exposure to vascular risk factors. Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass. We related LTL (measured by Southern blot analysis) to echocardiographic LV mass and its components (LV diastolic dimension, LVDD; LV wall thickness, LVWT) in 850 Framingham Heart Study participants (mean age 58 years, 58% women) using multivariable linear regression adjusting for age, sex, height, weight, systolic blood pressure, hypertension treatment, and smoking. Overall, multivariable-adjusted LTL was positively related to LV mass (beta coefficient per SD increase [β]=0.072; p= 0.001), LVWT (β=0.053; p= 0.01), and LVDD (β=0.035; p= 0.09). We observed effect modification by hypertension status (p for interaction =0.02 for LV mass); LTL was more strongly associated with LV mass and LVWT in individuals with hypertension (β per SD increment of 0.10 and 0.08, respectively; p<0.01 for both). Participants with hypertension who were in the top quartile of LV mass had LTL that was 250 base pairs longer relative to those in the lowest quartile (p for trend across quartiles 0.009). In contrast to our expectation, in our community-based sample, LTL was positively associated with LV mass and wall thickness, especially so in participants with hypertension. These data are consistent with the hypothesis that longer LTL may be a marker of propensity to LV hypertrophy.