Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans.
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans.
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DOI：
10.1186/s13148-022-01351-2
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发表时间：
2022-10-15
影响因子：
5.7
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中科院分区：
文献类型：
--
作者：
南亚人和欧洲人在非传染性疾病风险方面存在种族差异，遗传学和其他已知风险因素只能部分解释这种差异。DNA甲基化是一种未被探索的机制，可以解释疾病风险的差异。目前，人们对南亚和欧洲种族之间DNA甲基化的差异知之甚少。这项研究描述了来自两个英国队列的自我报告的欧洲和南亚种族个体之间血液DNA甲基化的差异：绍瑟尔和布伦特重访和出生在布拉德福德。不同种族之间的DNA甲基化差异在整个基因组中广泛存在（n = 16，433个CpG位点，3.4%的检测位点）。具体而言，76%的关联归因于细胞组成的种族差异，吸烟和遗传变异的影响较少。种族相关的CpG位点富集EWAS目录表型，包括代谢物。这项工作强调了在表观遗传学研究中考虑种族多样性的必要性。在线版本包含补充材料，可通过10.1186/s13148-022-01351-2获得。
Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently, there is little knowledge of how DNA methylation varies between South Asian and European ethnicities. This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts: Southall and Brent Revisited and Born in Bradford. DNA methylation differences between ethnicities were widespread throughout the genome (n = 16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity-associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research. The online version contains supplementary material available at 10.1186/s13148-022-01351-2.
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影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
8.2
作者：
Fraszczyk E;Spijkerman AMW;Zhang Y;Brandmaier S;Day FR;Zhou L;Wackers P;Dollé MET;Bloks VW;Gào X;Gieger C;Kooner J;Kriebel J;Picavet HSJ;Rathmann W;Schöttker B;Loh M;Verschuren WMM;van Vliet-Ostaptchouk JV;Wareham NJ;Chambers JC;Ong KK;Grallert H;Brenner H;Luijten M;Snieder H
通讯作者：
Snieder H
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
7.7
作者：
Galanter, Joshua M.;Gignoux, Christopher R.;Zaitlen, Noah
通讯作者：
Zaitlen, Noah
影响因子：
4.4
作者：
Michaud DS;Ruan M;Koestler DC;Pei D;Marsit CJ;De Vivo I;Kelsey KT
通讯作者：
Kelsey KT