Changes in the expression of alpha(v) integrins in oral squamous cell carcinomas
Changes in the expression of alpha(v) integrins in oral squamous cell carcinomas
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DOI：
10.1111/j.1600-0714.1997.tb00023.x
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发表时间：
1997-02-01
影响因子：
3.3
通讯作者：
Speight, PM
中科院分区：
文献类型：
--
作者：
Jones, J;Watt, FM;Speight, PM
整合素是调节正常细胞相互作用的细胞表面粘附分子;异常整合素表达被认为在肿瘤侵袭和转移中起作用。α（v）亚基能够与几个β亚基形成异源二聚体，但并不是所有在口腔上皮中表达的异源二聚体都被研究过。我们检测了α（v）整合素在正常颊粘膜和17例口腔鳞状细胞癌中的分布。α（v）亚基和α（v）β（5）异源二聚体的抗体染色正常上皮，在基底层中表达较强，在更浅表层中染色较弱。β（3）和β（6）亚基在正常上皮中不表达。抗-α（v）和抗-α（v）β（5）抗体染色所有鳞状细胞癌，但表达模式是可变的内部和之间的肿瘤。分化差的肿瘤显示最弱的染色，并且通常具有显示表达丧失的区域。β（6）在所有癌中表达，表明α（v）β（6）整联蛋白在恶性口腔上皮中的新表达。这些结果表明，α（v）整合素的改变可能有助于恶性上皮的行为，α（v）β（6）表达可能在肿瘤进展中发挥作用。
Integrins are cell surface adhesion molecules that regulate normal cellular interactions; aberrant integrin expression is believed to play a role in tumour invasion and metastasis. The alpha(v) subunit is capable of forming heterodimers with several beta subunits but not all the heterodimers expressed in oral epithelium have been investigated. We have examined the distribution of alpha(v) integrins in normal buccal mucosa and seventeen oral squamous cell carcinomas. Antibodies to the alpha(v) subunit and alpha(v) beta(5) heterodimer stained normal epithelium, with strong expression in the basal layers and weaker staining in the more superficial layers. The beta(3) and beta(6) subunits were not expressed in normal epithelium. Anti-alpha(v) and anti-alpha(v) beta(5) antibodies stained all the squamous cell carcinomas, but the pattern of expression was variable both within and between tumours. Poorly differentiated tumours showed the weakest staining and often had areas showing loss of expression. beta(6) was expressed in all of the carcinomas, indicating new expression of the alpha(v) beta(6) integrin in malignant oral epithelium. These results suggest that alterations in alpha(v) integrins may contribute to the behaviour of malignant epithelium and that alpha(v) beta(6) expression may play a role in tumour progression.