WAIT-AND-SEE POLICY IN CLINICAL STAGE-I NONSEMINOTAMOUS GERM-CELL TUMORS OF THE TESTIS
WAIT-AND-SEE POLICY IN CLINICAL STAGE-I NONSEMINOTAMOUS GERM-CELL TUMORS OF THE TESTIS
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睾丸临床 I 期非精原生殖细胞肿瘤的观望政策
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Oldhoff
中科院分区：
文献类型：
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作者：
H. Koops;D. Sleijfer;J. Oosterhuis;J. Marrink;H. Debruijn;J. Oldhoff
33例临床I期睾丸非腺瘤性生殖细胞肿瘤患者仅行睾丸切除术。非常仔细的随访-每3周进行一次肿瘤标志物检测，每6周进行一次胸部X光检查，每3个月进行一次肺部和腹膜后CT扫描-发现7名患者（21%）发生转移。所有这些复发都是在扁桃体切除术后6个月内诊断出来的。7例患者中有5例发现主动脉旁淋巴结转移，1例伴有腹股沟淋巴结转移，1例伴有肺转移; 2例患者仅有肺转移。7例复发患者中有6例接受化疗（PVB）; 1例拒绝化疗。鉴于残留疾病，进行了手术切除;结果显示坏死和成熟畸胎瘤。所有33例患者仍然存活，腰椎切除术后随访期为12-38个月。
: Thirty-three patients with a non-seminomatous germ cell tumor of the testis in clinical stage I were treated only by orchidectomy. The very careful follow-up--with tumor marker assays every 3 weeks, chest X-rays every 6 weeks and CT-scans of the lungs and retroperitoneum every 3 months--revealed metastases in 7 of the patients (21%). All these relapses were diagnosed within 6 months of the orchidectomy. Para-aortic node metastases were found in 5 of the 7 patients, with additional inguinal node metastases in 1 and additional lung metastases in 1; 2 patients had only lung metastases. Six of the 7 patients with a relapse were given chemotherapy (PVB); 1 patient refused chemotherapy. In view of residual disease a surgical excision was performed; it revealed necrosis as well as mature teratoma. All 33 patients are still alive, the post-orchidectomy follow-up period being 12-38 months.