Tobacco Use and Response to Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer.
Tobacco Use and Response to Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer.
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DOI：
10.3390/curroncol29090492
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发表时间：
2022-08-30
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
烟草是肺癌的已知危险因素，持续使用烟草与包括手术、化疗和放射治疗在内的多种肺癌治疗方式的预后较差有关。烟草使用和结果与免疫检查点抑制剂（ICIs）之间的关系尚不清楚，这正在成为肺癌治疗领域的重要组成部分，无论是在转移性还是治愈性环境中。我们回顾了烟草与肿瘤生物学的联系，因为它涉及到免疫治疗。我们还回顾了烟草使用与非小细胞肺癌（NSCLC）中使用ICIs的III期随机临床试验结果的关系。我们发现，在treatment-naïve （HR 0.82, 95% CI 0.69-0.97, vs. HR 1.06, 95% CI 0.81-1.38）和治疗前（HR 0.79, 95% CI 0.70-0.90 vs. 1.03, 95% CI 0.74-1.43）两种情况下，有吸烟史的患者接受ICI治疗可能比从不吸烟者获益更多。在进一步定义吸烟状况的试验中，与当前吸烟者相比，戒烟者似乎显示出更大的ICI治疗益处（HR 0.78, 95% CI 0.59-1.01比0.91,95% CI 0.72-1.14）。最后，我们提出了我们对该领域未来研究方向的看法，包括在涉及肺癌和其他疾病部位的ICI治疗的临床试验中实施标准化收集和烟草使用分析，以及评估烟草如何影响与ICI治疗相关的毒性。基于我们的综述，我们认为患者的吸烟史确实在指导肺癌患者的治疗决策中发挥了作用。
Tobacco is a known risk factor for lung cancer, and continued tobacco use is associated with poorer outcomes across multiple lung cancer treatment modalities including surgery, chemotherapy and radiation therapy. Less is known about the association of tobacco use and outcomes with immune checkpoint inhibitors (ICIs), which are becoming an important part of the treatment landscape in lung cancer, both in metastatic and curative settings. We reviewed the literature on the association of tobacco and tumor biology as it relates to immunotherapy. We also reviewed the association of tobacco use on outcomes among phase III randomized clinical trials involving ICIs in non-small cell lung cancer (NSCLC). We identified that patients with a smoking history may have a greater benefit with ICI treatment compared to never smokers in both treatment-naïve (HR 0.82, 95% CI 0.69–0.97, vs. HR 1.06, 95% CI 0.81–1.38) and pre-treated (HR 0.79, 95% CI 0.70–0.90 vs. 1.03, 95% CI 0.74–1.43) settings. In trials where smoking status was further defined, ex-smokers appear to demonstrate greater benefit with ICI therapy compared to current smokers (HR 0.78, 95% CI 0.59–1.01 vs. 0.91, 95% CI 0.72–1.14). We conclude by offering our perspective on future directions in this area of research, including implementation of standardized collection and analysis of tobacco use in clinical trials involving ICI therapy in lung cancer and other disease sites, and also evaluating how tobacco may affect toxicities related to ICI therapy. Based on our review, we believe that a patient’s history of tobacco smoking does have a role to play in guiding treatment decision making in patients with lung cancer.
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影响因子：
10.3
作者：
Desrichard, Alexis;Kuo, Fengshen;Morris, Luc G. T.
通讯作者：
Morris, Luc G. T.
DOI：
10.1200/jco.20.01605
发表时间：
2021-03-01
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Borghaei H;Gettinger S;Vokes EE;Chow LQM;Burgio MA;de Castro Carpeno J;Pluzanski A;Arrieta O;Frontera OA;Chiari R;Butts C;Wójcik-Tomaszewska J;Coudert B;Garassino MC;Ready N;Felip E;García MA;Waterhouse D;Domine M;Barlesi F;Antonia S;Wohlleber M;Gerber DE;Czyzewicz G;Spigel DR;Crino L;Eberhardt WEE;Li A;Marimuthu S;Brahmer J
通讯作者：
Brahmer J
DOI：
10.1158/1078-0432.ccr-15-3101
发表时间：
2016-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gainor JF;Shaw AT;Sequist LV;Fu X;Azzoli CG;Piotrowska Z;Huynh TG;Zhao L;Fulton L;Schultz KR;Howe E;Farago AF;Sullivan RJ;Stone JR;Digumarthy S;Moran T;Hata AN;Yagi Y;Yeap BY;Engelman JA;Mino-Kenudson M
通讯作者：
Mino-Kenudson M
影响因子：
2.8
作者：
El-Osta, Hazem;Jafri, Syed
通讯作者：
Jafri, Syed
IV期或复发性非小细胞肺癌中的一线Nivolumab。
DOI：
10.1056/nejmoa1613493
发表时间：
2017-06-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Carbone DP;Reck M;Paz-Ares L;Creelan B;Horn L;Steins M;Felip E;van den Heuvel MM;Ciuleanu TE;Badin F;Ready N;Hiltermann TJN;Nair S;Juergens R;Peters S;Minenza E;Wrangle JM;Rodriguez-Abreu D;Borghaei H;Blumenschein GR Jr;Villaruz LC;Havel L;Krejci J;Corral Jaime J;Chang H;Geese WJ;Bhagavatheeswaran P;Chen AC;Socinski MA;CheckMate 026 Investigators
通讯作者：
CheckMate 026 Investigators