Diminished response to an inhibitory signal in lymphocytes from patients with systemic lupus erythematosus.
Diminished response to an inhibitory signal in lymphocytes from patients with systemic lupus erythematosus.
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DOI：
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发表时间：
1988-03
影响因子：
4.6
通讯作者：
M. Salata;J. Golbus;B. Richardson
中科院分区：
文献类型：
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作者：
M. Salata;J. Golbus;B. Richardson
Systemic lupus erythematosus is an autoimmune disease characterized by B-cell hyperactivity, resulting in polyclonal hypergammaglobulinaemia. One mechanism potentially resulting in excessive immunoglobulin synthesis is a diminished response to inhibitory signals. To test this hypothesis, anti-IgG antisera was used to inhibit pokeweed mitogen activation of cultured lymphocytes from lupus patients and controls. Inhibition of IgG secretion by B cells from lupus patients required more than 75 times as much anti-IgG as normal controls (P less than 0.005), indicating that lupus lymphocytes are hyporesponsive to this inhibitory signal. Similar studies with DR3+ controls demonstrated that diminished responsiveness to anti-IgG inhibition may in part be associated with the HLA-DR3 allele. Defects in this inhibitory mechanism may play a role in the B-cell hyperactivity observed in lupus.
