Informed choice about breast cancer prevention: randomized controlled trial of an online decision aid intervention.
Informed choice about breast cancer prevention: randomized controlled trial of an online decision aid intervention.
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DOI：
10.1186/bcr3468
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Fagerlin A
中科院分区：
文献类型：
--
作者：
Korfage IJ;Fuhrel-Forbis A;Ubel PA;Zikmund-Fisher BJ;Greene SM;McClure JB;Smith DM;Alford SH;Fagerlin A
他莫昔芬和雷洛昔芬是化学预防药物，可以将女性患原发性乳腺癌的相对风险降低50%;然而，大多数符合这些药物条件的女性选择不服用它们。使用率低的原因可能与妇女对毒品的知识或态度有关。我们的目的是研究在线乳腺癌化学预防决策辅助（DA）对乳腺癌高危女性的知情意图和决策的影响。我们进行了一项随机临床试验，评估了关于乳腺癌化学预防的DA对化学预防知情选择的影响。女性（n = 585），46- 74岁，完成在线基线，后测试和三个月的随访问卷。参与者被随机分配到一个干预组，一个标准对照组，在基线时回答有关化学预防的问题，或一个三个月的对照组，在基线时不回答有关化学预防的问题。主要结果的措施是妇女的意图和决定，化学预防药物是否知情，以及妇女谁看DA是否更有可能作出知情的决定比妇女谁不看DA，使用二分复合变量“知情选择”（是/否）分类知情的决定，反映了足够的知识和一致性之间的妇女的决定和相关的态度。分析表明，干预组比标准对照组（52.7%比5.9%）在后测时做出了更多的明智决定，P <0.001。在3个月随访时，干预组（16.9%）和两个对照组（11.8%和8.0%）之间的知情选择率差异无统计学意义，P = 0.067。DA增加了关于乳腺癌化学预防的知情决策，尽管对知识的影响随着时间的推移而减少。这项研究并不是为了确定决策者随着时间的推移必须保留多少知识。审查知情的决定可以增加对DA影响的理解。需要有一个标准来界定和衡量作出知情决定所需的充分知识。ClinicalTrials.gov：NCT00967824
Tamoxifen and raloxifene are chemopreventive drugs that can reduce women's relative risk of primary breast cancer by 50%; however, most women eligible for these drugs have chosen not to take them. The reasons for low uptake may be related to women's knowledge or attitudes towards the drugs. We aimed to examine the impact of an online breast cancer chemoprevention decision aid (DA) on informed intentions and decisions of women at high risk of breast cancer. We conducted a randomized clinical trial, assessing the effect of a DA about breast cancer chemoprevention on informed choices about chemoprevention. Women (n = 585), 46- to 74-years old old, completed online baseline, post-test, and three-month follow-up questionnaires. Participants were randomly assigned to either an intervention group, a standard control group that answered questions about chemoprevention at baseline, or a three-month control group that did not answer questions about chemoprevention at baseline. The main outcome measures were whether women's intentions and decisions regarding chemoprevention drugs were informed, and whether women who viewed the DA were more likely to make informed decisions than women who did not view the DA, using a dichotomous composite variable 'informed choice' (yes/no) to classify informed decisions as those reflecting sufficient knowledge and concordance between a woman's decision and relevant attitudes. Analyses showed that more intervention than standard control participants (52.7% versus 5.9%) made informed decisions at post-test, P <0.001. At the three-month follow-up, differences in rates of informed choice between intervention (16.9%) and both control groups (11.8% and 8.0%) were statistically non-significant, P = 0.067. The DA increased informed decision making about breast cancer chemoprevention, although the impact on knowledge diminished over time. This study was not designed to determine how much knowledge decision makers must retain over time. Examining informed decisions increases understanding of the impact of DAs. A standard for defining and measuring sufficient knowledge for informed decisions is needed. ClinicalTrials.gov: NCT00967824
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影响因子：
3.8
作者：
Fagerlin, Angela;Dillard, Amanda J.;Smith, Dylan M.;Zikmund-Fisher, Brian J.;Pitsch, Rosemarie;McClure, Jennifer B.;Greene, Sarah;Alford, Sharon Hensley;Nair, Vijayan;Hayes, Daniel F.;Wiese, Cheryl;Ubel, Peter A.
通讯作者：
Ubel, Peter A.
DOI：
10.1111/j.1467-842x.2003.tb00397.x
发表时间：
2003-06-01
影响因子：
3.5
作者：
Donovan, RJ;Jalleh, G;Jones, SC
通讯作者：
Jones, SC
妇女关于他莫昔芬预防乳腺癌的决定：对量身定制的决策援助的反应。
影响因子：
3.8
作者：
Fagerlin, Angela;Zikmund-Fisher, Brian J.;Smith, Dylan M.;Nair, Vijayan;Derry, Holly A.;McClure, Jennifer B.;Greene, Sarah;Stark, Azadeh;Alford, Sharon Hensley;Lantz, Paula;Hayes, Daniel F.;Wiese, Cheryl;Zweig, Sarah Claud;Pitsch, Rosemarie;Jankovic, Aleksandra;Ubel, Peter A.
通讯作者：
Ubel, Peter A.
影响因子：
--
作者：
Mathieu, Erin;Barratt, Alexandra;Houssami, Nehmat
通讯作者：
Houssami, Nehmat
DOI：
10.1046/j.1369-6513.2003.00195.x
发表时间：
2003-03-01
期刊：
Health expectations : an international journal of public participation in health care and health policy
影响因子：
--
作者：
Stacey, Dawn;O'Connor, Annette M;Verma, Shailendra
通讯作者：
Verma, Shailendra