THE REPRODUCIBILITY OF THE ORAL GLUCOSE-TOLERANCE TEST OVER LONG (5 YEARS) AND SHORT PERIODS (1 WEEK)
THE REPRODUCIBILITY OF THE ORAL GLUCOSE-TOLERANCE TEST OVER LONG (5 YEARS) AND SHORT PERIODS (1 WEEK)
复制标题
DOI：
10.1007/bf01477070
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
CREUTZFELDT, W
中科院分区：
文献类型：
--
作者：
KOBBERLING, J;KERLIN, A;CREUTZFELDT, W
对312名非糖尿病亲属进行了为期10年的三次口服葡萄糖耐量试验（oGTT）。在第二项研究中，在55名个体中以每周间隔进行6次相同的oGTT。在本研究中，根据对数值计算的方差按以下顺序增加：空腹（0.026）、1 h（0.035）、2 h（0.044）和3 h值（0.047）。1 h和2 h值的总和显示最低方差（0.024）。在43名进行长期和短期研究的个体中，方差均无显著差异。因此，在较长时间内观察到的葡萄糖总方差的大部分仅代表随机变化。这种随机变化远高于可能影响oGTT结果的大多数其他因素。基于单个oGTT的诊断价值有限。
Three oral glucose tolerance tests (oGTT) have been performed in 312 non-diabetic relatives of diabetics over a period of 10 years. In a second study 6 identical oGTT's have been performed at weekly intervals in 55 individuals. In this study the variance, calculated from the logarithmic values, increased in the following order: fasting (0.026), 1 h (0.035), 2 h (0.044) and 3 h values (0.047). The sum of the 1 h and 2 h values showed the lowest variance (0.024). No significant difference of the variances was found in the 43 individuals in whom both the long-term and the short-term studies have been performed. Thus, a great proportion of the total variance of glucose observed over longer periods only represents a random variation. This random variation is much higher than most other factors which might influence the result of an oGTT. A diagnosis based on a single oGTT is of only limited value.