Age-dependent consequences of status epilepticus: animal models.
Age-dependent consequences of status epilepticus: animal models.
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癫痫持续状态的年龄依赖性后果：动物模型。
DOI：
10.1111/j.1528-1167.2007.01069.x
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发表时间：
2007
期刊：
影响因子：
5.6
通讯作者：
Moshé,SolomonL
中科院分区：
文献类型：
--
作者：
Scantlebury,MorrisH;Heida,JamesG;Hasson,HenryJ;Velísková,Jana;Velísek,Libor;Galanopoulou,AristeaS;Moshé,SolomonL
癫痫持续状态（SE）是一种重要的神经系统急症，最常见于儿童。尽管SE与脑损伤风险升高有关，但临床研究尚不清楚哪些人以及在什么情况下会发生脑损伤。本综述的目的是评估年龄对SE后果的影响。在这篇综述中，我们主要集中在描述成年和未成熟大鼠脑中单次SE诱导的后果的动物数据。实验数据表明，发生SE诱导的脑损伤、随后的癫痫和认知缺陷的风险在很大程度上取决于SE发生的年龄。年轻的大鼠比年老的大鼠更能抵抗癫痫引起的脑损伤；然而，当SE发生在大脑异常的未成熟大鼠时，癫痫引起的脑损伤的严重程度会增加。更好地了解SE引起的年龄特异性大脑改变的病理生理机制，将有助于开发新的有效策略来改善其有害后果。
Status epilepticus (SE) is a significant neurological emergency that occurs most commonly in children. Although SE has been associated with an elevated risk of brain injury, it is unclear from clinical studies in whom and under what circumstances brain injury will occur. The purpose of this review is to evaluate the effects of age on the consequences of SE. In this review, we focus mainly on the animal data that describe the consequences of a single episode of SE induced in the adult and immature rat brain. The experimental data suggest that the risk of developing SE‐induced brain damage, subsequent epilepsy and cognitive deficits in large part depends on the age in which the SE occurs. Younger rats are more resistant to seizure‐induced brain damage than older rats; however, when SE occurs in immature rats with abnormal brains, there is an increase in the severity of seizure‐induced brain injury. Better understanding of the pathophysiologic mechanisms underlying the age‐specific alterations to the brain induced by SE will lead to the development of novel and effective strategies to improve the deleterious consequences.