Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.
Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.
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DOI：
10.1101/cshperspect.a012161
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发表时间：
2013-04
影响因子：
5.4
通讯作者：
T. Wills;D. Winder
中科院分区：
文献类型：
--
作者：
T. Wills;D. Winder
The extended amygdala is a series of interconnected, embryologically similar series of nuclei in the brain that are thought to play key roles in aspects of alcohol dependence, specifically in stress-induced increases in alcohol-seeking behaviors. Plasticity of excitatory transmission in these and other brain regions is currently an intense area of scrutiny as a mechanism underlying aspects of addiction. N-methyl-D-aspartate (NMDA) receptors (NMDARs) play a critical role in plasticity at excitatory synapses and have been identified as major molecular targets of ethanol. Thus, this article will explore alcohol and NMDAR interactions first at a general level and then focusing within the extended amygdala, in particular on the bed nucleus of the stria terminalis (BNST).
