Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma
Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma
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DOI：
10.1186/s12917-014-0240-5
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发表时间：
2014-10-08
影响因子：
2.6
通讯作者：
Brodbelt, David C.
中科院分区：
文献类型：
--
作者：
Summers, Jennifer F.;Hendricks, Anke;Brodbelt, David C.
背景：人们担心兽用抗菌药物的使用可能会增加对人类健康至关重要的细菌的耐药性水平。犬脓皮病是宠物犬中常见且经常复发的诊断，通常归因于皮肤继发细菌感染。病变的严重程度取决于受影响组织的位置、总面积和深度，建议采用抗菌治疗来解决。本研究旨在描述大量英国初级保健犬脓皮病病例中的患者信号、疾病特征和治疗方案，并估计英国兽医就诊犬群中脓皮病的患病率。结果：2010 年，在 73 个参与诊所就诊的 54,600 只狗中，有 683 只 (1.3%) 的脓皮病诊断记录在可用的电子病历 (EPR) 数据中。 97% 的病例都使用了抗菌药物，大多数狗都接受了全身治疗 (92%)。最常用的药物是阿莫西林克拉维酸、头孢氨苄、克林霉素和头孢维星。在详细审查的研究病例中，约 40% 的全身抗菌药物处方时间少于 14 天。 43 只狗中有 26% 的每日处方剂量低于最低推荐每日剂量 (MRDD)，其中有足够的信息来计算最小剂量。结论：治疗犬脓皮病的抗菌药物处方行为各不相同，但经常与当前建议不一致。使用来自初级实践 EPR 的临床数据可以提供对常见临床状况和相关处方的宝贵见解。
Background: Concern has been raised regarding the potential contributions of veterinary antimicrobial use to increasing levels of resistance in bacteria critically important to human health. Canine pyoderma is a frequent, often recurrent diagnosis in pet dogs, usually attributable to secondary bacterial infection of the skin. Lesions can range in severity based on the location, total area and depth of tissue affected and antimicrobial therapy is recommended for resolution. This study aimed to describe patient signalment, disease characteristics and treatment prescribed in a large number of UK, primary-care canine pyoderma cases and to estimate pyoderma prevalence in the UK vet-visiting canine population.Results: Of 54,600 dogs presented to 73 participating practices in 2010, 683 (1.3%) had a pyoderma diagnosis recorded in available electronic patient record (EPR) data. Antimicrobials were dispensed in 97% of cases and most dogs were prescribed systemic therapy (92%). Agents most frequently prescribed were amoxicillin-clavulanate, cefalexin, clindamycin and cefovecin. Systemic antimicrobials were prescribed for fewer than 14 days in around 40% of study cases reviewed in detail. Prescribed daily doses were below minimum recommended daily dose (MRDD) in 26% of 43 dogs with sufficient information for calculation of minimum dose.Conclusions: Antimicrobial prescribing behaviour for treatment of canine pyoderma was variable but frequently appeared inconsistent with current recommendations. Use of clinical data from primary practice EPRs can provide valuable insight into common clinical conditions and associated prescribing.