Gender difference in the association and presentation of visual hallucinations in dementia with Lewy bodies: a cross-sectional study
Gender difference in the association and presentation of visual hallucinations in dementia with Lewy bodies: a cross-sectional study
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DOI：
10.1002/gps.4706
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Tsai, Chun-Tang
中科院分区：
文献类型：
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作者：
Chiu, Pai-Yi;Teng, Po-Ren;Tsai, Chun-Tang
目的视觉幻觉(VHS)是路易体痴呆(DLB)最显著的特征之一。方法对一项关于痴呆的前瞻性纵向研究的基线数据进行横断面分析。总结和比较男女DLB患者VHS的累积频度、1个月频度和现象学。结果152例患者中，女性65例(42.8%)，男性87例(57.2%)。VHS的累积频率和1个月频率女性分别为60%和55.4%，男性分别为44.8%和41.4%。调整年龄和疾病严重程度后，VH组比非VH组纳入了更多的女性[优势比(OR)=2.33，p=0.028]。在女性参与者中，年龄较大(OR=9.16，p=0.003)和较高的神经精神症状评分(OR=4.89，p=0.009)与VHS有关，而在男性参与者中，较严重的痴呆阶段(临床痴呆评分2~3分与临床痴呆评分0.5分，OR=6.22，p=0.008)和较高的抗精神病药物使用率(OR=9.64，p=0.047)与VHS有关。与VHS相关的因素在女性和男性患者中的模式不同。版权所有(C)2017 John Wiley&Sons，Ltd.
ObjectiveVisual hallucinations (VHs) are among the most striking features of dementia with Lewy bodies (DLB). We investigated gender differences in the association and presentation of VHs in DLB.MethodsA cross-sectional analysis of baseline data from a prospective, longitudinal study on dementia was performed. Cumulative frequency, 1-month frequency, and phenomenology of VHs were summarized and compared between female and male patients with DLB. Gender differences in the factors associated with VHs were investigated in patients with and without hallucinations.ResultsA total of 152 patients including 65 (42.8%) women and 87 (57.2%) men were analyzed. The cumulative and 1-month frequencies of VHs were 60% and 55.4%, respectively, in women and 44.8% and 41.4%, respectively, in men. Adjusting for age and disease severity resulted in the inclusion of more women in the VH group [odds ratio (OR)=2.33, p=0.028)] than in the non-VH group. In female participants, older age (OR=9.16, p=0.003) and higher neuropsychiatric inventory score (OR=4.89, p=0.009) were associated with VHs, whereas in male participants, more severe dementia stage (clinical dementia rating 2-3 versus clinical dementia rating 0.5, OR=6.22, p=0.008) and higher rates of using antipsychotics (OR=9.64, p=0.047) were associated with VHs.ConclusionThe frequencies of 1-month and cumulative VHs were high in DLB, which indicated a high prevalence as well as a high persistency of VHs in DLB. The patterns of factors associated with VHs differed between female and male patients. Copyright (c) 2017 John Wiley & Sons, Ltd.