A facile preparation of imidazolinium chlorides.
A facile preparation of imidazolinium chlorides.
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DOI：
10.1021/ol800628a
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发表时间：
2008-04
期刊：
影响因子：
5.2
通讯作者：
Kevin M Kuhn;R. Grubbs
中科院分区：
文献类型：
--
作者：
Kevin M Kuhn;R. Grubbs
描述了一种制备对称和不对称咪唑氯化物的方法，该方法包括甲双胺与二氯乙烷和碱(A)的反应。这种方法可以在无溶剂的反应条件下得到大量的咪唑氯化物，并且只需简单的过滤就可以得到高纯度的咪唑氯化物。或者，通过使用一半的甲双胺中间体作为牺牲碱(B)，可以从取代的苯胺以中等的产率直接制备对称的咪唑氯化物。
A process for the preparation of symmetric and unsymmetric imidazolinium chlorides that involves reaction of a formamidine with dichloroethane and a base (a) is described. This method makes it possible to obtain numerous imidazolinium chlorides under solvent-free reaction conditions and in excellent yields with purification by simple filtration. Alternatively, symmetric imidazolinium chlorides can be prepared directly in moderate yields from substituted anilines by utilizing half of the formamidine intermediate as sacrificial base (b).