The cell as the smallest DNA-based molecular computer
The cell as the smallest DNA-based molecular computer
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DOI：
10.1016/s0303-2647(99)00039-8
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发表时间：
1999-10-01
期刊：
影响因子：
1.6
通讯作者：
Ji, S
中科院分区：
文献类型：
--
作者：
Ji, S
Adleman（1994）的开创性工作证明，试管中的DNA分子可以被操纵来执行某种类型的数学计算。这激发了人们对构建基于DNA的分子计算机的可能性的理论兴趣。为了衡量实现这种微观计算机的实用性，人们认为有必要尽可能多地从活细胞的生物学中学习-目前已知的唯一存在的基于DNA的分子计算机。本文简要回顾了最近发展起来的活细胞理论模型（博帕尔托）及其相关的理论（如细胞语言）、原理、定律和概念（如整合子、IDS），并以“分子符号学”（同义词包括“微符号学”）五定律的形式加以总结。“细胞符号学”或“细胞符号学”）-研究在细胞和分子水平上介导测量、计算和通信的符号。希望这些定律能在设计基于DNA的计算系统中得到实际应用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
The pioneering work of Adleman (1994) demonstrated that DNA molecules in test tubes can be manipulated to perform a certain type of mathematical computation. This has stimulated a theoretical interest in the possibility of constructing DNA-based molecular computers. To gauge the practicality of realizing such microscopic computers, it was thought necessary to learn as much as possible from the biology of the living cell-presently the only known DNA-based molecular computer in existence. Here the recently developed theoretical model of the living cell (the Bhopalator) and its associated theories (e.g. cell language), principles, laws and concepts (e.g. conformons, IDS's) are briefly reviewed and summarized in the form of a set of five laws of 'molecular semiotics' (synonyms include 'microsemiotics'. 'cellular semiotics', or 'cytosemiotics')-the study of signs mediating measurement, computation, and communication on the cellular and molecular levels. Hopefully, these laws will find practical applications in designing DNA-based computing systems. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.