Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008
Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008
复制标题
DOI：
10.1016/j.neuro.2010.12.006
复制
发表时间：
2011-03-01
期刊：
影响因子：
3.4
通讯作者：
Lee, Byung-Kook
中科院分区：
文献类型：
--
作者：
Kim, Yangho;Lee, Byung-Kook
简介：我们提供了2008年韩国国家健康和营养检查调查（KNHANES）的数据，该调查涉及韩国成年人群代表性样本的血锰（Mn）水平分布及其与铁缺乏症的关系。该研究基于KNHANES 2008获得的数据，这项研究进行了三年，（2007-2009）使用滚动抽样设计，涉及一个复杂的，分层的，多阶段的，概率聚类调查的代表性样本的非制度化的平民人口在韩国。低血清铁蛋白组女性、男性和所有参与者的血锰几何平均值（GM）均显著高于正常组。女性和所有参与者血清铁蛋白正常值低组的血锰GM均显著高于正常组。此外，在控制了性别、年龄、地域、教育程度、吸烟和饮酒状况等协变量后进行的多元回归分析显示，与正常组相比，女性、男性和所有参与者的低铁蛋白组的血Mn显著较高，而仅女性和所有参与者的低正常铁蛋白组的血Mn显著较高。目前的研究表明，缺铁会增加一般人群的血锰水平。据我们所知，本研究是第一个显示血锰水平和铁蛋白水平之间的关联，在一个代表性的样本的成年人口，如在KNHANES评估。(C)2010年爱思唯尔公司All rights reserved.
Introduction: We present data from Korean National Health and Nutritional Examination Survey (KNHANES) 2008 on the distribution of blood manganese (Mn) levels and their associations with iron deficiency in a representative sample of the adult Korean population.Methods: This study was based on data obtained in KNHANES 2008, which was conducted for three years (2007-2009) using a rolling sampling design that involves a complex, stratified, multistage, probability-cluster survey of a representative sample of the noninstitutionalized civilian population in South Korea.Results: Geometric means (GMs) of blood Mn in the low serum ferritin group in women, men, and all participants were significantly higher than in the normal group. GMs of blood Mn in the low-normal serum ferritin groups in women and all participants were significantly higher than in the normal group. In addition, multiple regression analysis after controlling for covariates including gender, age, regional area, education level, and smoking and drinking status showed that blood Mn was significantly higher in the low ferritin group in women, men, and all participants compared with the normal group, whereas blood Mn was significantly higher in the low-normal ferritin group only in women and all participants.Discussion: The present study shows that iron deficiency increases blood Mn level in the general population. To the best of our knowledge, the present study is the first to show an association between blood Mn level and ferritin level in a representative sample of the adult population such as that evaluated in KNHANES. (C) 2010 Elsevier Inc. All rights reserved.