The impact of lung microbiota dysbiosis on inflammation
The impact of lung microbiota dysbiosis on inflammation
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DOI：
10.1111/imm.13139
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发表时间：
2020-02
期刊：
影响因子：
6.4
通讯作者：
Daping Yang;Yangang Xing;Xinyang Song;Youcun Qian
中科院分区：
文献类型：
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作者：
Daping Yang;Yangang Xing;Xinyang Song;Youcun Qian
宿主-微生物群相互作用在粘膜免疫稳态中起着重要作用。肠道菌群失调已被证明参与多种免疫反应和许多多因素疾病。对肠道微生物群的研究已经超越了生态失调的后果，进入了与疾病相关的因果微生物群。然而，对肺部微生物群及其生态失调的研究仍处于起步阶段。培养依赖型和非培养依赖型技术的进步促进了我们对肺微生物群的了解，这些微生物群不仅存在于健康的肺组织中，而且在生理和病理条件下对免疫反应都有很大的影响。在这篇综述中，我们总结了肺微生物群失调的最新进展及其对决定耐受性和炎症平衡的局部免疫系统的影响。我们讨论了疾病环境下肺生态失调的原因，并提出肺微生物群与宿主之间的相互作用对建立肺免疫稳态至关重要。
Host−microbiota interaction plays fundamental roles in the homeostasis of mucosal immunity. Dysbiosis of intestinal microbiota has been demonstrated to participate in various immune responses and many multifactorial diseases. Study of intestinal microbiota has moved beyond the consequences of dysbiosis to the causal microbiota associated with diseases. However, studies of pulmonary microbiota and its dysbiosis are still in their infancy. Improvement of culture‐dependent and ‐independent techniques has facilitated our understanding of lung microbiota that not only exists in healthy lung tissue but also exerts great impact on immune responses under both physiological and pathological conditions. In this review, we summarize recent progresses of lung microbiota dysbiosis and its impact on the local immune system that determines the balance of tolerance and inflammation. We discuss the causal roles of pulmonary dysbiosis under disease settings, and propose that the interaction between lung microbiota and host is critical for establishing the immune homeostasis in lung.