Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome
Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome
复制标题
DOI：
10.1097/psy.0b013e31820a59c0
复制
发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Penninx, Brenda W. J. H.
中科院分区：
文献类型：
--
作者：
Luppino, Floriana S.;Dortland, Arianne K. B. van Reedt;Penninx, Brenda W. J. H.
目的：使用维度方法研究抑郁和焦虑症状与代谢综合征 (MetSyn) 之间的关联。一方面，抑郁症和焦虑症之间的关联，另一方面，MetSyn 作为一个簇或其各个组成部分之间的关联是模棱两可的。 《精神疾病诊断和统计手册》第四版的分类性质可能部分解释了不一致的发现。方法：在 2,433 名荷兰抑郁和焦虑研究参与者中（平均年龄 42.3 岁；33.1% 男性），三个症状维度——缺乏积极情感（PA，抑郁症特异性）；负面影响（NA，非特异性）；和躯体唤起（SA，特定焦虑）——通过情绪和焦虑症状问卷的简化版进行评估。使用线性回归分析，分析症状维度和 MetSyn 成分（腰围、甘油三酯、高密度脂蛋白胆固醇、葡萄糖和平均血压）之间的关联。结果:: MetSyn 的发生率为 20.1% (n = 490)。 SA（而非 PA 和 NA）与五分之四的 MetSyn 成分密切相关，尤其是腰围、甘油三酯和血压（分别为 beta = 0.046，p = .01；beta = 0.077，p < .001；和 beta = 0.069，p < .001），并且与 MetSyn 成分总数（13 = 0.098，p < .001）密切相关。 .001）。结论：我们的结果表明大多数 MetSyn 成分与 SA 维度有很强的关联，但与 NA 和 PA 维度没有很强的关联。
Objective: To investigate the association between depression and anxiety symptoms and the metabolic syndrome (MetSyn), using a dimensional approach. The association between depression and anxiety, on the one hand, and the MetSyn as a cluster or its individual components, on the other hand, is equivocal. The categorical nature of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition might partly explain the inconsistent findings. Methods: In 2,433 Netherlands Study of Depression and Anxiety participants (mean age, 42.3 years; 33.1% male), three symptoms dimensions-lack of positive affect (PA, depression specific); negative affect (NA, aspecific); and somatic arousal (SA, anxiety specific)-were assessed by a shortened adaptation of the Mood and Anxiety Symptom Questionnaire. The association between symptom dimensions and MetSyn components (waist circumference, triglycerides high-density lipoprotein cholesterol, glucose, and mean blood pressure) was analyzed, using linear regression analysis. Results:: The occurrence rate of the MetSyn was 20.1% (n = 490). SA, but not PA and NA, was strongly associated with four out of five MetSyn components, especially waist circumference, triglycerides, and blood pressure (beta = 0.046, p = .01; beta = 0.077, p < .001; and beta = 0.069, p < .001, respectively), and with the total number of MetSyn components (13 = 0.098, p < .001). Conclusions: Our results demonstrate a strong association of most of the MetSyn components with the SA dimension, but not with the NA and PA scales.