Analysis of Bile Acids
Analysis of Bile Acids
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DOI：
10.1023/b135931_10
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Goto, Junichi
中科院分区：
文献类型：
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作者：
Sjovall, Jan;Griffiths, William J.;Goto, Junichi
胆汁酸构成脊椎动物中的类固醇的大家族，通常由胆固醇形成并且在可变长度的侧链中携带羧基。胆汁醇，也是由胆固醇形成的，除了在类固醇骨架中不存在羧基之外，具有与胆汁酸相似的结构。从定量和调节的角度来看，胆固醇向胆汁酸和/或胆汁醇的转化对于维持胆固醇稳态都是非常重要的（Chiang，2004; Kalaany和Mangelsdorf，2006;摩尔、加藤、谢等人，2006; Scotti，Gilardi，Godio等人，2007年）。适当结合的胆汁酸和胆汁醇（也称为胆汁盐）在胆汁中分泌，并在脂质和脂溶性化合物的吸收中发挥重要作用（Hofmann，2007）。可靠的分析方法是研究生物体中胆汁酸和胆汁醇的功能和病理生理重要性所必需的。当与遗传和蛋白质组学研究相结合时，这些小分子的分析（在今天的术语中：代谢组学，类固醇组学，类固醇组学，类胆固醇组学等）将导致对脂质代谢中的综合代谢过程的更深入的理解。
Bile acids constitute a large family of steroids in vertebrates, normally formed from cholesterol and carrying a carboxyl group in a side-chain of variable length. Bile alcohols, also formed from cholesterol, have similar structures as bile acids, except for the absence of a carboxyl group in the steroid skeleton. The conversion of cholesterol to bile acids and/or bile alcohols is of major importance for maintenance of cholesterol homeostasis, both from quantitative and regulatory points of view (Chiang, 2004; Kalaany and Mangelsdorf, 2006; Moore, Kato, Xie, et al., 2006; Scotti, Gilardi, Godio, et al., 2007). Appropriately conjugated bile acids and bile alcohols (also referred to as bile salts) are secreted in bile and serve vital functions in the absorption of lipids and lipid-soluble compounds (Hofmann, 2007). Reliable analytical methods are required for studies of the functions and pathophysiological importance of the variety of bile acids and bile alcohols present in living organisms. When combined with genetic and proteomic studies, analysis of these small molecules (in today’s terminology: metabolomics, steroidomics, sterolomics, cholanoidomics, etc.) will lead to a deeper understanding of the integrated metabolic processes in lipid metabolism.