Reference optical phantoms for diffuse optical spectroscopy. Part 1-Error analysis of a time resolved transmittance characterization method
Reference optical phantoms for diffuse optical spectroscopy. Part 1-Error analysis of a time resolved transmittance characterization method
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DOI：
10.1364/oe.18.011495
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发表时间：
2010-05-24
期刊：
影响因子：
3.8
通讯作者：
Mermut, Ozzy
中科院分区：
文献类型：
--
作者：
Bouchard, Jean-Pierre;Veilleux, Israel;Mermut, Ozzy
光学仿组织体模的开发、生产质量控制和校准需要一种方便、可靠、具有已知绝对精度的表征方法。我们提出了一种固体幻影表征技术的基础上，通过一个相对较小的幻影样品的光的时间分辨透射率测量。样品的小尺寸使得能够表征在常规模体生产中生产的每个材料批次。对时间分辨透射率数据进行预处理，以校正暗噪声、样品厚度和仪器响应函数。然后将预处理的数据与基于辐射传递方程的正演模型进行比较，该模型通过Monte Carlo模拟精确地考虑到样品的有限几何形状来求解。通过建立预先计算结果的查找表并使用插值来获得光学性质的中间值处的建模透射率迹线，减轻了蒙特-卡罗技术的计算负担。使用时间分辨透射率迹线最大值的1%以上的所有数据，通过拟合窗口获得接近完美的拟合残差。该方法的绝对准确性估计通过一个彻底的误差分析，其中考虑到以下贡献：测量噪声，系统的重复性，仪器响应函数的稳定性，样品厚度变化的折射率不准确性，时间相关的单光子计数系统基于时间的不准确性和前向模型的不准确性。对吸收系数和约化散射系数的绝对误差估计分别为0.01 cm（-1）（11.3%）和0.67 cm（-1）（6.8%）。(C)2010年美国光学学会
Development, production quality control and calibration of optical tissue-mimicking phantoms require a convenient and robust characterization method with known absolute accuracy. We present a solid phantom characterization technique based on time resolved transmittance measurement of light through a relatively small phantom sample. The small size of the sample enables characterization of every material batch produced in a routine phantoms production. Time resolved transmittance data are pre-processed to correct for dark noise, sample thickness and instrument response function. Pre-processed data are then compared to a forward model based on the radiative transfer equation solved through Monte Carlo simulations accurately taking into account the finite geometry of the sample. The computational burden of the Monte-Carlo technique was alleviated by building a lookup table of pre-computed results and using interpolation to obtain modeled transmittance traces at intermediate values of the optical properties. Near perfect fit residuals are obtained with a fit window using all data above 1% of the maximum value of the time resolved transmittance trace. Absolute accuracy of the method is estimated through a thorough error analysis which takes into account the following contributions: measurement noise, system repeatability, instrument response function stability, sample thickness variation refractive index inaccuracy, time correlated single photon counting system time based inaccuracy and forward model inaccuracy. Two sigma absolute error estimates of 0.01 cm(-1) (11.3%) and 0.67 cm(-1) (6.8%) are obtained for the absorption coefficient and reduced scattering coefficient respectively. (C) 2010 Optical Society of America