Occupational hazards and the onset of natural menopause
Occupational hazards and the onset of natural menopause
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职业危害和自然更年期的开始
DOI：
10.1016/j.maturitas.2022.08.012
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发表时间：
2022
期刊：
影响因子：
4.9
通讯作者：
Jianhong Zhou
中科院分区：
文献类型：
--
作者：
Linjuan Ma;Tongyun Qi;Yue Zhang;Yizhou Huang;Saisai Li;Qian Ying;Zhaoqiang Jiang;Chunming Li;Peiqiong Chen;Wenxian Xu;Yibing Lan;Ketan Chu;Jianlin Lou;Wenlan Yu;Jianhong Zhou
摘要目的探讨职业危害因素与自然绝经期提前的关系。研究设计：采用全国性横断面研究，探讨中国女工的生殖健康状况。最终样本量为17，948。主要结果测量参与者完成了一个自我报告工具，记录工作条件，化学和物理制剂的职业环境，社会经济因素，生活方式，生育史和职业信息。考克斯回归模型被用来检查每一个职业危害和绝经期开始之间的关联。结果异常工作量（19.31%）、芳香族化合物（7.95%）和噪声（24.94%）分别是作业条件、化学性和物理性职业病危害因素中最常见的3种。在调整后的每种危险分析中，异常工作量（HR = 1.133，p = 0.038）、噪音（HR = 1.233，p p = 0.041）与自然绝经年龄提前相关。在包括所有可能的职业危害后，只有噪声（HR = 1.187，p = 0.003）仍具有统计学意义。结论：在一项对17,948名女工的全国性调查中，本研究调查了自然绝经年龄与多种职业危害的关系，其中一些尚未得到解决。职业噪声首次被确定为生殖衰老的危险因素。然而，还需要进一步的研究来证实我们的发现。
AbstractObjective To identify occupational hazards associated with earlier onset of natural menopause. Study design A national cross-sectional study was conducted to explore the reproductive health of Chinese female workers. The final sample size was 17,948. Main outcome measures Participants completed a self-report instrument that recorded working conditions, chemical and physical agents in the occupational environment, socioeconomic factors, lifestyle, reproductive history, and occupational information. A Cox regression model was used to examine the association between each occupational hazard and onset of menopause. Results Abnormal workload (19.31 %), aromatic compounds (7.95 %), and noise (24.94 %) were the three most frequently self-reported occupational hazards in the three categories of working conditions, chemical agents, and physical agents, respectively. Abnormal workload (HR = 1.133, p = 0.038), noise (HR = 1.233, p p = 0.041) were associated with earlier age at natural menopause in the analyses of each hazard, after adjustment. Only noise (HR = 1.187, p = 0.003) remained statistically significant after including all possible occupational hazards. Conclusions In a national survey of 17,948 female workers, this study investigated the association of age at natural menopause with multiple occupational hazards, some of which have not been addressed. Occupational noise was identified as a risk factor for reproductive senescence for the first time. However, further research is needed to confirm our findings.