Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.
Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.
复制标题
白细胞介素 2 调节正常细胞和抑制细胞培养物产生的免疫干扰素 (IFN gamma)。
作者：
B. Torres;W. Farrar;H. Johnson
Lyt-2+淋巴细胞负责在有丝分裂原刺激的小鼠脾细胞培养物中产生免疫干扰素（IFN γ）。诱导IFN γ需要Lyt-1+辅助细胞。白细胞介素2（IL 2）可以特异性地替代Lyt 1细胞的需要。IL-2也会消除抑制细胞对IFN-γ产生的抑制作用. IFN γ的产生似乎是由辅助细胞（IL 2的来源）、抑制细胞（IL 2的吸收？）和IFN γ生产细胞。
A Lyt-2+ lymphocyte is responsible for immune interferon (IFN gamma) production in mitogen-stimulated mouse spleen cell cultures. A Lyt-1+ helper cell is required for the induction of IFN gamma. Interleukin 2 (IL 2) can specifically replace the Lyt 1 cell requirement. IL 2 will also abrogate suppressor cell inhibition of IFN gamma production. IFN gamma production appears to be regulated by a dynamic interaction between helper cells (source of IL 2), suppressor cells (absorption of IL 2?) and IFN gammna-producer cells.