Nitric oxide functions as a signal in plant disease resistance
Nitric oxide functions as a signal in plant disease resistance
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作者：
Delledonne, M;Xia, YJ;Lamb, C
对无毒病原体的识别触发了活性氧中间体超氧化物（O-2（-））和过氧化氢（H2 O2）的快速产生（1）。这种氧化爆发驱动细胞壁的交联（2），诱导参与细胞保护和防御的几种植物基因（3，4），并且是在过敏性抗病反应中启动宿主细胞死亡所必需的（1，3）。然而，这种爆发不足以支持强大的抗病反应（4，5）。在这里，我们表明，一氧化氮作为免疫、神经和血管系统中的信号（6），通过活性氧中间体增强大豆细胞中过敏性细胞死亡的诱导，并独立于这些中间体发挥作用，以诱导合成保护性天然产物的基因。此外，一氧化氮合成的抑制剂损害拟南芥叶片对假单胞菌的超敏感抗病反应，促进疾病和细菌生长。我们的结论是，一氧化氮在植物抗病性中起着关键作用。
Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O-2(-)) and hydrogen peroxide (H2O2)(1). This oxidative burst drives crosslinking of the cell wall(2), induces several plant genes involved in cellular protection and defence(3,4), and is necessary for the initiation of host cell death in the hypersensitive disease-resistance response(1,3). However, this burst is not enough to support a strong disease-resistance response(4,5). Here we show that nitric oxide, which acts as a signal in the immune, nervous and vascular systems(6), potentiates the induction of hypersensitive cell death in soybean cells by reactive oxygen intermediates and functions independently of such intermediates to induce genes for the synthesis of protective natural products. Moreover, inhibitors of nitric oxide synthesis compromise the hypersensitive disease-resistance response of Arabidopsis leaves to Pseudomonas syringae, promoting disease and bacterial growth. We conclude that nitric oxide plays a key role in disease resistance in plants.