AN EPSTEIN-BARR VIRUS EARLY PROTEIN INDUCES CELL-FUSION
AN EPSTEIN-BARR VIRUS EARLY PROTEIN INDUCES CELL-FUSION
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DOI：
10.1073/pnas.78.11.7162
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
WOLF, H
中科院分区：
文献类型：
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作者：
BAYLISS, GJ;WOLF, H
用EB病毒（EBV）重复感染Raji [人淋巴母细胞样]细胞导致合胞体形成。使用代谢抑制剂和氨基酸类似物的研究表明，融合诱导因子属于病毒特异性蛋白的早期组。各种化学物质诱导Raji细胞中的早期EBV蛋白合成也导致合胞体形成，表明融合过程不是由感染后引入细胞的病毒体膜蛋白引起的。讨论了这些发现与EB病毒与[人类淋巴母细胞瘤]相关性的相关性。
Superinfection of Raji [human lymphoblastoid] cells with Epstein-Barr virus (EBV) leads to syncytium formation. Studies using metabolic inhibitors and amino acid analogs suggest that the fusion-inducing factor belongs to the early group of virus-specified proteins. Induction of early EBV protein synthesis in Raji cells by various chemicals also leads to syncytium formation, indicating that the fusion process is not caused by a virion membrane protein introduced into the cells upon infection. The relevance of these findings to the association of EBV with [human lymphoblastoid] is discussed.