Skin Commensal Antigens: Taking the Road Less Traveled.
Skin Commensal Antigens: Taking the Road Less Traveled.
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皮肤共生抗原：走少有人走的路。
DOI：
10.1016/j.it.2018.02.001
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发表时间：
2018
影响因子：
16.8
通讯作者：
Scharschmidt,TiffanyC
中科院分区：
文献类型：
--
作者：
Dhariwala,MiqdadO;Scharschmidt,TiffanyC
尽管我们对宿主-宿主相互作用的了解呈指数级增长，但连接特定宿主的机制、免疫系统对其的检测以及其对组织功能的影响仍然常常知之甚少。在最近的一项研究中，Linehan等人在皮肤的背景下剖析了这些相互作用之一，并证明表皮葡萄球菌抗原通过非经典途径呈递，驱动促进伤口愈合的CD 8 +T细胞的积累。
Although our knowledge of host–commensal interactions has increased exponentially, the mechanisms linking a specific commensal, its detection by the immune system, and its impact on tissue function are still often poorly understood. In a recent study inCell, Linehanet al. dissect one of these interactions in the context of the skin, and demonstrate thatStaphylococcus epidermidisantigens, presented through a non-classical pathway, drive the accumulation of CD8+T cells that promote wound healing.