The effect of lead toxicity and milk deprivation of myelination in the rat.
The effect of lead toxicity and milk deprivation of myelination in the rat.
复制标题
铅中毒和缺奶对大鼠髓鞘形成的影响。
DOI：
10.1016/0041-008x(85)90186-3
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发表时间：
1985
影响因子：
3.8
通讯作者：
Morell,P
中科院分区：
文献类型：
--
作者：
Harry,GJ;Toews,AD;Krigman,MR;Morell,P
在特定的产后发育期间，即产后第 2 天至第 28 天，大鼠每天口服每公斤体重 200 毫克铅（醋酸铅），并进行 8 小时母乳剥夺计划，或两种攻击的组合。第29天，将老鼠杀死。无论是铅暴露还是单独的牛奶剥夺都会降低大脑（10%）和身体（15%）的重量，并且在同时暴露于铅和牛奶的大鼠中观察到附加效应（大脑：20%；身体：35%）。单独的铅或剥夺损伤都不会在髓鞘形成过程中产生扰动。然而，当这两种情况结合在一起时，相互作用很明显，女性髓鞘质积累减少了 25%。在男性中没有看到效果。女性的髓鞘形成缺陷是特定的，因为神经胶质原纤维酸性蛋白（星形胶质细胞的标记）和神经丝蛋白（神经元，特别是轴突的标记）的积累都没有受到干扰。组织铅浓度并不表明女性敏感性的增加是由于她们体内铅负荷的选择性增加所致。
During a defined postnatal developmental period, the 2nd through the 28th postnatal day, rats were exposed daily to either an oral administration of 200 mg lead (as lead acetate) per kilogram of body weight, and 8-hr maternal milk deprivation schedule, or a combination of the two insults. On the 29th day the rats were killed. Either lead exposure or milk deprivation alone decreased brain (10%) and body (15%) weights, and an additive effect was observed in rats exposed to both lead and milk deprivation (brain: 20%; body: 35%). Neither the lead nor the deprivation insult alone produced a perturbation in the process of myelination. However, when the two conditions were combined an interaction was evident as a 25% decrease in myelin accumulation in females. No effect was seen in males. The myelination deficit in females was specific in that neither accumulation of glial fibrillary acidic protein (a marker for astroglial cells) nor neurofilament protein (a marker for neurons, especially axons) was perturbed. Tissue lead concentrations did not suggest that this increased sensitivity in females was due to a selective increase in their body burden of lead.