Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes.
Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes.
复制标题
健康眼睛黄斑视网膜和脉络膜结构的扫描源光学相干断层扫描成像
DOI：
10.1186/s12886-015-0110-3
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发表时间：
2015-09-17
影响因子：
2
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang J;Gao X;Huang W;Wang W;Chen S;Du S;Li X;Zhang X
BackgroundTo报告的厚度的视网膜，视网膜神经节细胞（RGC）相关层，脉络膜在健康受试者使用扫描源光学相干断层扫描（SS-OCT）。Methods 146名健康志愿者连续招募这项前瞻性观察研究。使用一个SS-OCT（DRI OCT-1，Topcon，日本）自动测量糖尿病视网膜病变研究（ETDRS）标准早期治疗网格中的视网膜、RGC相关层和脉络膜厚度。结果黄斑神经节细胞复合体（GCC）和神经节细胞内丛状层（GCIPL）的平均厚度分别为105.3 ± 9.7和78.5 ± 6.2 μ m。两者均与视网膜厚度有较强的相关性（r = 0.793，p = 0.000; r = 0.813，p = 0.000），视网膜内的地形分布相似。视网膜的厚度和GCC/GCIPL的内部部门的EDTRS区的显着高于外部部门，而在同一地区的黄斑，脉络膜表现出完全不同的地形变化模式。经年龄和AL校正后，男性视网膜厚度比女性厚7.8 μ m，脉络膜厚度比女性厚34.9 μ m（均P < 0.05）。年龄和AL对脉络膜厚度有显著影响，但对视网膜无显著影响（p < 0.05）。结论健康中国人GCC/GCIPL厚度在不同性别、年龄和AL组间无显著差异，但性别对视网膜和脉络膜厚度有重要影响。脉络膜结构（但不是视网膜）可以受到年龄和AL的显著影响。
BackgroundTo report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT).MethodsOne hundred and forty-six healthy volunteers were consecutively recruited for this prospective observational study. Thickness of retina, RGC-related layers, and choroid in the standard early treatment of diabetic retinopathy study (ETDRS) grid were automatically measured using one SS-OCT (DRI OCT-1, Topcon, Japan). The IOL Master (Carl Zeiss Meditec, Germany) was used to measure axial length (AL).ResultsThicknesses of the average macular ganglion cell complex (GCC) and ganglion cell-inner plexiform layer (GCIPL) were 105.3 ± 9.7 and 78.5 ± 6.2 um respectively. Neither of them was significantly related with sex, age, or AL. Both showed strong correlations with retinal thickness (r = 0.793,p= 0.000; r = 0.813,p= 0.000, respectively) and with similar topographic distributions within the retina. The thicknesses of retina and GCC/GCIPL in the inner sectors were significantly higher than in the outer sectors of the EDTRS area, while in the same region of the macula, the choroid exhibited completely different patterns of topographic variation. Men had 7.8 um thicker retina and 34.9 um thicker choroid than women after adjustment for age and AL (allp< 0.05). Age and AL could significantly influence the choroidal thickness but not the retina (allp< 0.05).ConclusionThickness of GCC/GCIPL in healthy Chinese individuals is not dramatically different across gender, age, and AL groups in terms of ETDRS grid, but sex is critical for retinal and choroidal thickness. Choroidal structure (but not retinal) can be significantly influenced by age and AL.