Correlation between change in body weight rather than current body weight and change in serum adiponectin levels in a Japanese population - the Funagata study
Correlation between change in body weight rather than current body weight and change in serum adiponectin levels in a Japanese population - the Funagata study
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DOI：
10.1016/j.metabol.2005.09.005
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发表时间：
2006-03-01
影响因子：
9.8
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Arawaka, N;Daimon, M;Kato, T
肥胖者血清脂联素水平降低。我们研究了当前体重（BW）及其变化与血清脂联素水平变化的关系。基线血清脂联素水平（1995 - 1997年）和5年随访（2000年至2002年）对1003次考试进行了评估，（男/女，425/578;基线检查时的年龄，58.3 ± 11.7/57.5 ± 11.0岁）来自Funagata研究队列人群（N = 2013）的日本受试者。检查基线检查时的BW和基线与随访检查之间的BW变化（Δ BW）与研究期间血清脂联素水平变化（Δ脂联素）的相关性和关联性。逐步回归分析显示Δ BW（男性和女性分别为r =-0.233和-0.204;女性中基于体重指数划分的上三分位组为r =-0.324）与Δ脂联素显著相关。然而，两种性别动物基线检查时的BW无显著相关性。多因素logistic回归分析显示，体重减少2 kg或以上的受试者分别是对照组的2.56倍（95%置信区间，1.21 - 5.42; P =.014）和8.24倍（95%置信区间，3.59 - 18.9; P
Serum adiponectin levels are decreased in obese subjects. We examined the association of current body weight (BW) and its change with a change in serum adiponectin levels. Serum adiponectin levels at the baseline (from 1995 to 1997) and the 5-year follow-up (from 2000 to 2002) examinations were evaluated in 1003 (M/F, 425/578; age at the baseline examinations, 58.3 +/- 11.7/57.5 +/- 11.0 years) Japanese subjects from a cohort population (N = 2013) of the Funagata study. Correlations and associations of BW at the baseline examinations and changes in BW between the baseline and the follow-up examinations (delta BW) with changes in the serum adiponectin levels in the study period (delta Adiponectin) were examined. Stepwise regression analyses revealed a significant correlation of the delta BW (r = -0.233 and -0.204 for men and women, respectively; r = -0.324 for the upper tertile group divided based on their body mass index in women) with the delta Adiponectin. However, the BW at the baseline examinations was not significantly correlated in both sexes. Multiple logistic regression analyses revealed that subjects who reduced their BW by 2 kg or more were 2.56 (95% confidence interval, 1.21-5.42; P =.014) and 8.24 times (95% confidence interval, 3.59-18.9;P