Knockdown of metadherin inhibits angiogenesis in breast cancer
Knockdown of metadherin inhibits angiogenesis in breast cancer
复制标题
麦粘蛋白的敲除可抑制乳腺癌中的血管生成。
DOI：
10.3892/ijo.2015.2973
复制
发表时间：
2015-06-01
影响因子：
5.2
通讯作者：
Yang, Qifeng
中科院分区：
文献类型：
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作者：
Liu, Yan;Kong, Xiangnan;Yang, Qifeng
血管生成在肿瘤的生长、侵袭和转移中起重要作用。已证实元粘附素（MTDH）与血管生成相关。然而，MTDH对血管生成的详细机制尚未报道。在这项研究中，我们证明了MTDH在乳腺癌中的抗血管生成功能。通过RNA干扰策略，我们发现MTDH的敲低抑制了体外和离体细胞的血管生成。此外，我们发现ERK 1/2通路参与MTDH的抗血管生成功能，并且该功能可以通过上调microRNA-21（miR-21）而部分逆转。总之，MTDH的敲低可以抑制乳腺癌中的血管生成。这些结果表明MTDH是乳腺癌中抗血管生成的可行治疗靶标。
Angiogenesis plays an important role in cancer growth, invasion and metastasis. It has been confirmed that metadherin (MTDH) is associated with angiogenesis. However, the detailed mechanism of MTDH on angiogenesis has not yet been reported. In this study, we demonstrate the anti-angiogenic function of MTDH in breast cancer. With RNA interference strategies, we found that knockdown of MTDH inhibits cellular angiogenesis both in vitro and ex vivo. Furthermore, we revealed that ERK1/2 pathway is involved in the anti-angiogenic function of MTDH, and the function can be partially reversed via upregulation of microRNA-21 (miR-21). In conclusion, knockdown of MTDH can inhibit angiogenesis in breast cancer. These results show that MTDH is a viable therapeutic target for anti-angiogenesis in breast cancer.