Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
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DOI：
10.1016/s0969-9961(03)00017-2
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发表时间：
2003-06-01
影响因子：
6.1
通讯作者：
MacLeod, N
中科院分区：
文献类型：
--
作者：
Curtis, J;Errington, M;MacLeod, N
我们研究了不同年龄的PrP基因携带无效突变的小鼠海马中的突触功能。在两个实验室进行的体内和体外实验显示，在青少年和年轻的成年人控制和PrP-null小鼠表达长时程增强，成对脉冲促进，或强直后增强无论是在齿状回或在CA 1区的能力没有差异。然而，我们发现一个显着减少的水平强直后增强和长时程增强的CA 1区的老年PrP-null小鼠。这些结果进行了讨论，在老年人的PrP-null小鼠的氧化应激水平增加的关系。(C)2003 Elsevier Science（美国）。All rights reserved.
We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-term potentiation, paired-pulse facilitation, or posttetanic potentiation in either the dentate gyrus or in the CA1 region. However, we found a significant reduction in the level of posttetanic potentiation and long-term potentiation in the CA1 region of aged PrP-null mice. These results are discussed in relationship to reported increased levels of oxidative stress in older PrP-null mice. (C) 2003 Elsevier Science (USA). All rights reserved.