The complement system in teleosts
The complement system in teleosts
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DOI：
10.1006/fsim.2001.0408
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发表时间：
2002-05-01
影响因子：
4.7
通讯作者：
Lambris, JD
中科院分区：
文献类型：
--
作者：
Holland, MCH;Lambris, JD
补体是先天免疫系统的重要组成部分，由大约35种单独的蛋白质组成。在哺乳动物中，补体的活化导致产生活化的蛋白质片段，其在微生物杀伤、吞噬作用、炎症反应、免疫复合物清除和抗体产生中发挥作用。鱼类似乎具有与哺乳动物相似的激活途径，迄今为止鉴定的鱼类补体蛋白与哺乳动物补体蛋白具有许多同源性。由于有关鱼类中补体蛋白、调节蛋白和补体受体的信息还远未完全，因此尚不清楚在哺乳动物中鉴定的所有补体功能是否也存在于鱼类中。然而，已经清楚地证明，鱼补体可以溶解外来细胞并调理外来生物体以被吞噬细胞破坏。也有迹象表明，补体片段参与炎症反应。鱼类具有多种补体蛋白的多种同种型，如C3和因子B。已经假设，补体蛋白中的这种多样性的功能用于扩展其先天免疫识别能力和应答。了解鱼类中补体的功能和单个蛋白质（包括各种亚型）在宿主防御中的作用，不仅对于了解该系统的演变而且对于制定鱼类健康管理的新策略都很重要。(C)2002爱思唯尔科技有限公司版权所有。
Complement, an important component of the innate immune system, is comprised of about 35 individual proteins. In mammals, activation of complement results in the generation of activated protein fragments that play a role in microbial killing, phagocytosis, inflammatory reactions, immune complex clearance, and antibody production. Fish appear to possess activation pathways similar to those in mammals, and the fish complement proteins identified thus far show many homologies to their mammalian counterparts. Because information about complement proteins, regulatory proteins, and complement receptors in fish is far from complete, it is unclear whether all the complement functions that have been identified in mammals also occur in fish. However, it has been clearly demonstrated that fish complement can lyse foreign cells and opsonise foreign organisms for destruction by phagocytes. There are also indications that complement fragments participate in inflammatory reactions. Fish possess multiple isoforms of several complement proteins, such as C3 and factor B. It has been hypothesised that the function of this diversity in complement proteins serves to expand their innate immune recognition capacity and response. Understanding the functions of complement in fish and the roles the individual proteins, including the various isoforms, play in host defence, is important not only for understanding the evolution of this system but also for the development of new strategies in fish health management. (C) 2002 Elsevier Science Ltd. All rights reserved.