The effects of leptin receptor (LEPR) and melanocortin-4 receptor (MC4R) polymorphisms on fat content, fat distribution and fat composition in a Duroc x Landrace/Large White cross
The effects of leptin receptor (LEPR) and melanocortin-4 receptor (MC4R) polymorphisms on fat content, fat distribution and fat composition in a Duroc x Landrace/Large White cross
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DOI：
10.1016/j.livsci.2012.01.010
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发表时间：
2012-05-01
影响因子：
1.8
通讯作者：
Lopez-Buesa, P.
中科院分区：
文献类型：
--
作者：
Galve, A.;Burgos, C.;Lopez-Buesa, P.
在杜洛克×长白猪/大白色猪杂交中研究了突变LEPR c.1987 C>T和MC 4 R c.1426 G>A对参与食欲调节的瘦素受体和黑皮质素受体基因的影响。据我们所知，这是第一次报告的存在LEPR c.1987C>T的影响以外的伊比利亚品种或伊比利亚与其他品种的杂交。这两种突变都改变了与脂肪组织含量相关的几个性状。与LEPR CC猪相比，LEPR TT猪的胴体中富含肌肉组织的关节百分比较低，富含脂肪组织的关节百分比较高（腰部较轻5.8%，猪油较重6.0%）。与LEPR CC纯合子猪相比，LEPR TT猪的火腿（8.0%）和肩部（24%）中的脂肪组织含量也更高。他们也有较大的背膘厚度值（1.5和7.5毫米之间，取决于解剖位置）。与LEPR CC猪相比，LEPR TT猪以单不饱和和多不饱和脂肪酸含量为代价显示出饱和脂肪酸含量的明显增加。MC 4 R GG猪在胴体中具有较高的富含肌肉组织的关节百分比和较低的富含脂肪组织的关节百分比（6.3%较重的腰部和4.7%较轻的猪油），在火腿中具有较低的脂肪覆盖率和较高的肌肉分数（分别为9.3%和3.4%），并且在B中具有较大的脂肪含量。肌肉质量（12.2%）和全腿肌肉质量（8.6%）高于MC 4 R AA猪。虽然这两种突变的大多数影响可以通过增加摄食量来解释，但LEPR c.1987C>T对几个解剖位置中饱和脂肪酸含量的强烈影响可能是由于受损的瘦素信号传导系统的局部影响。选择这些突变的腌肉生产的后果进行了讨论。(C)2012 Elsevier BM. All rights reserved.
The effects of mutations LEPR c.1987C>T and MC4R c.1426G>A on leptin receptor and melanocortin receptor genes, which are involved in regulating appetite, have been studied in a Duroc x Landrace/Large White cross. To the best of our knowledge, this is the first report of the presence of LEPR c.1987C>T effects outside the Iberian breed or crosses of Iberian with other breeds. Both mutations modify several traits related to adipose tissue content. LEPR TT pigs have a lower percentage of joints rich in muscle tissue and a higher percentage of joints rich in adipose tissue in the carcass (5.8% lighter loins, 6.0% heavier lard) than LEPR CC pigs. LEPR TT pigs also have a greater adipose tissue content in their hams (8.0%) and shoulders (24%) than LEPR CC homozygous pigs. They also have larger backfat thickness values (between 1.5 and 7.5 mm depending on anatomical location). LEPR TT pigs show a clear increase in saturated fatty acid content at the expense of monounsaturated and polyunsaturated content when compared to LEPR CC pigs. MC4R GG pigs have a higher percentage of joints rich in muscle tissue and a lower percentage of joins rich in adipose tissue in the carcass (6.3% heavier loins and 4.7% lighter lard), lower fat cover and higher muscle fraction in hams (9.3% and 3.4%, respectively), and a larger fat content in B. femoris (12.2%) and in whole ham muscle mass (8.6%) than MC4R AA pigs. Whereas most effects of both mutations can be explained by an increase in feed intake, the strong effects of LEPR c.1987C>T on saturated fatty acid content in several anatomical locations are probably due to the local effect of a compromised leptin signaling system. The consequences of selecting these mutations for cured meat production are discussed. (C) 2012 Elsevier BM. All rights reserved.