Thermal molecular focusing: tunable cross effect of phoresis and light-driven hydrodynamic focusing
Thermal molecular focusing: tunable cross effect of phoresis and light-driven hydrodynamic focusing
复制标题
DOI：
10.1039/c8sm00754c
复制
发表时间：
2018-07-14
期刊：
影响因子：
3.4
通讯作者：
Maeda, Yusuke T.
中科院分区：
文献类型：
--
作者：
Fukuyama, Tatsuya;Nakama, Sho;Maeda, Yusuke T.
通过微观电泳或流体动力学平流来控制溶质通量是传输分子的基本方式，分子在自然界和技术中普遍存在。我们研究了在聚合物溶液中由随时间变化的热场驱动的大溶质如DNA的运输。一个热点的热传播来回移动引起DNA的分子聚焦与频率可调控制。我们开发了一个模型，其中一个解决方案的粘弹性膨胀和一个较小的溶质的粘度梯度耦合，这解释了底层的流体动力学聚焦。这种效应以频率可调的方式提供了对软材料和生物材料的新型非侵入性操作。
The control of solute flux by either microscopic phoresis or hydrodynamic advection is a fundamental way to transport molecules, which are ubiquitously present in nature and technology. We study the transport of large solutes such as DNA driven by a time-dependent thermal field in a polymer solution. Heat propagation of a heat spot moving back and forth gives rise to the molecular focusing of DNA with frequency-tunable control. We develop a model where the viscoelastic expansion of a solution and the viscosity gradient of a smaller solute are coupled, which explains the underlying hydrodynamic focusing. This effect offers novel non-invasive manipulation of soft and biological materials in a frequency-tunable manner.