CORRELATION OF THE EFFICIENCY OF FATTY-ACID DERIVATIVES IN SUPPRESSING PLASMODIUM-FALCIPARUM GROWTH IN CULTURE WITH THEIR INHIBITORY EFFECT ON ACYL-COA SYNTHETASE-ACTIVITY
CORRELATION OF THE EFFICIENCY OF FATTY-ACID DERIVATIVES IN SUPPRESSING PLASMODIUM-FALCIPARUM GROWTH IN CULTURE WITH THEIR INHIBITORY EFFECT ON ACYL-COA SYNTHETASE-ACTIVITY
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DOI：
10.1016/0166-6851(88)90177-6
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发表时间：
1988-02-01
影响因子：
1.5
通讯作者：
VIAL, HJ
中科院分区：
文献类型：
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作者：
BEAUMELLE, BD;VIAL, HJ
红细胞内的疟疾寄生虫依赖于周围的介质提供磷脂前体。用修饰的脂肪酸对恶性疟原虫的体外生长有有效的抑制作用(IC50为7~90微米)。在培养中最有效地抑制恶性疟原虫生长的脂肪酸类似物也是猴子寄生虫诺氏疟原虫的酰基辅酶A合成酶最活跃的抑制剂。
The intraerythrocytic malaria parasite depends on the surrounding medium for a supply of phospholipid precursors. Efficient inhibition (IC50 7-90 .mu.M) of Plasmodium falciparum growth in vitro was achieved using modified fatty acids. The fatty acid analogues most effective in suppressing P. falciparum growth in culture were also the most active inhibitors of acyl-CoA synthetase from the monkey parasite P. knowlesi.