The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research.
The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research.
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DOI：
10.1097/jnn.0b013e3182527690
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Crowe M
中科院分区：
文献类型：
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作者：
Sartori AC;Vance DE;Slater LZ;Crowe M
越来越多的证据表明，炎症水平，免疫反应，随着年龄的增长，整个身体和大脑。炎症对大脑的影响，无论是急性还是慢性，都与老年人的认知能力下降和痴呆症风险有关。据信增加炎症的因素包括某些与健康相关的行为，如吸烟，不良饮食和不活动，以及糖尿病，高血压和慢性阻塞性肺病等健康状况，其中大多数需要医疗干预和监测。因此，护士和医疗保健专业人员可能会遇到未来发生炎症相关认知能力下降的高风险患者。炎症过程及其与老年人认知功能的关系的综述，沿着可能增加或减少炎症的因素。实践和研究的影响进行了讨论。
Accumulating evidence suggests that levels of inflammation, an immune response, increase with age throughout the body and the brain. The effects of inflammation on the brain, both acute and chronic, have been associated with cognitive decline and risk of dementia in older adults. Factors believed to increase inflammation include certain health-related behaviors, such as smoking, poor diet, and inactivity as well as health conditions like diabetes, hypertension, and chronic obstructive pulmonary disease, most of which require medical intervention and monitoring. As such, nurses and healthcare professionals are likely to encounter patients who are at a high risk for future development of inflammation-related cognitive decline. A review of inflammatory processes and their relation to cognitive function in older adults is provided, along with factors that may increase or reduce inflammation. Implications for practice and research are discussed.